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The Acrodisc® WBC Premium Syringe Filter Saves Time, Providing Higher Cell Recoveries from Smaller Sample Volumes

Pall Life Sciences - Laboratory, Food, Beverage
21 Jul 2014
Sonia Nicholas
Managing Editor and Clinical Lead

Product news

Pall Life Sciences, a global industry leader in filtration, separation and purification, will be launching the Acrodisc WBC (white blood cell) premium syringe filter, a proven sample preparation device for the laboratory at AACC, July 29th, 2014.

The Acrodisc WBC is used to capture and recover leukocytes and for the separation of erythrocytes (red blood cells) and platelets from whole blood samples. The premium syringe filter removes >90% of the leukocytes from whole blood samples, which results in the collection of a greater population of enriched red blood cells (RBCs) from the sample. The RBCs can then be used in a variety of cellular and antigenic analyses. The captured leukocytes may also be used in further analysis, e.g., in various immune or gene expression studies.

The Acrodisc WBC isolation syringe filter contains Pall’s patented and proven Leukosorb® media, a fibrous matrix that is specially designed for blood cell separation procedures. Another key feature, the Effective Filtration Area (EFA) enables faster filtration and separation of the sample, which translates to very low hold up volumes. These key features working in tandem — the EFA combined with the capacity of the Leukosorb media to efficiently separate blood cells — result in higher cell recoveries from smaller sample volumes.

The Acrodisc WBC is ideally suited for a wide range of research applications such as antigen specificity and modulation studies, immune receptor analysis, receptor protein studies, genotyping, gene expression, and cell therapy.

The Acrodisc WBC premium syringe filter is being launched at the 2014 American Association for Clinical Chemistry (AACC) Annual Meeting and Clinical Lab Expo, Pall Life Sciences Booth No. 3540. Pall representatives will be on hand to answer questions and provide more information about the Acrodisc WBC and Pall’s complete line of leading membrane products.

The Acrodisc WBC premium syringe filter is for research use only, not intended for diagnostic purposes.

Pall, Acrodisc, and Leukosorb are trademarks of Pall Corporation. ® indicates a trademark registered in the USA.

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Acrodisc® WBC Syringe Filter

Pall Life Sciences - Laboratory, Food, Beverage

Pall Life Sciences' Acrodisc WBC premium syringe filter is an innovative filtration device designed specifically for use in the capture and recovery of Leukocytes and the separation of red blood cells. The Acrodisc WBC filter contains Pall's patented Leukosorb media. Leukosorb is a fibrous matrix that uses a multimodal approach of size exclusion and adsorption to capture and recover leukocytes from whole blood samples while allowing Red Blood Cells (RBCs) and platelets to flow through the membrane. With the Acrodisc WBC, the uniquely designed filter does all the difficult capture work, resulting in more efficient white blood cell separation as compared to Buffy Coat density gradient methods. The Acrodisc WBC yields greater cell capture and recovery with less sample compared to larger filter formats and also exudes very low hold up volume as compared to larger white blood cell isolation filters (hold up volume   Applications: Antigenic specificity Antigen modulation studies Cell receptor analysis Lymphocyte recovery for cell therapy Stem cell research applications  

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Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Clinical MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AACCThe American Association for Clinical Chemistry (AACC) Annual Meeting and Clinical Lab Expo is the largest meeting for clinical laboratory professionals in the world. This year's meeting is being held in Atlanta, USA, July 26th-30th, 2015.

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