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TEMIS Text Analytics Solution to Support Laboratoires Fournier’s Drug Discovery Process

TEMIS S.A.
29 Nov 2007

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TEMIS, leading provider of Text Analytics software solutions for the Life Science industry announced today that they have entered in a strategic software and services agreement with Laboratoires Fournier, a French affiliate of Solvay Pharmaceuticals. Laboratoires Fournier have chosen TEMIS acclaimed Text Analytics solution to accelerate their drug discovery process.

Solvay Pharmaceuticals seeks to fulfil carefully selected, unmet medical needs in several therapeutic areas. As a strategic part of this group, Laboratoires Fournier’s Exploratory Biology Unit (EBU) takes part in this global goal by discovering substances which could be used as an indicator of a biological state and so-called biomarkers.

In order to accelerate its biomarkers identification, Laboratoires Fournier has chosen to strengthen its drug discovery process with Luxid® for Life Sciences, the leading text analytics solution enabling targeted and efficient knowledge extraction from the ever-growing biomedical literature.

“At Solvay Pharmaceuticals, we decided to implement the Luxid® for Life Sciences software in our drug discovery process in order to facilitate an up-to-date synthesis and sharing of scientific information extracted by means of three Skill Cartridges™ dedicated to relationships of biological, medical, and chemical entities, and we are currently working with TEMIS on the development of a specific Skill Cartridge™ for biomarkers discovery. We are convinced of the valuable contribution of this text mining approach to the search for validated and potential biomarkers”, said Sébastien Vachenc, Bioinformatician - EBU Department at Laboratoires Fournier.

Laboratoires Fournier and TEMIS started collaborating in September 2005. After a successful pilot project, several users adopted the technology and progressively applied it to various studies. Today Laboratoires Fournier wishes to continue applying Text Analytics to highlight a selection of potential biomarker candidates before the pre-clinical studies. For the Biomarkers project, the Biological and Medical Skill Cartridges™ are used to detect specific relationships between diseases and proteins.

“We at TEMIS are committed in the long term to serving the global needs of our valued customer Laboratoires Fournier”, said Guillaume Mazières, VP Sales and Marketing of TEMIS. “We provide them with highly innovative capabilities for analysis, interpretation and highlighting of results, allowing for a richer navigation experience and turning text into knowledge for every user.”

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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Data MiningData mining is an important process for extracting information, patterns and trends from data. Data mining software, databases, reference materials and storage packages are available to process lab data.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :

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TEMIS Text Analytics Solution to Support Laboratoires Fournier’s Drug Discovery Process