Sub ambient synthesis of novel gold organometallic complexes

Asynt reports upon the synthesis of novel Gold (Au) organometallic complexes for use by researchers in the School of Chemistry at the University of Bristol (UK) achieved using a DrySyn SnowStorm Reactor and DrySyn Splitter Manifold.

The aim of the research being undertaken at the University of Bristol was to create new Au(I) organometallic complexes for use in gold-mediated cross-coupling reactions. Subsequent transmetallation with an organozinc reagent and reductive elimination led to the formation of products with new C-C bonds. The use of gold in these transformations has been shown to offer advantages over the traditionally used Palladium (Pd(0)/Pd(II)), including increased biocompatibility, improved functional group tolerance and better price stability.

During the described research it was discovered that the success of the transmetallation step was highly dependent on the temperature at which it was undertaken. Researchers at the University of Bristol invested in a DrySyn SnowStorm Reactor fitted with DrySyn vial inserts to give them the capability of performing up to 12 low-temperature reactions in parallel at a reliable and consistent temperature. By connecting the SnowStorm Reactor to a DrySyn Splitter Manifold the group were also able to utilize the recirculating chiller with other equipment in the lab, maximizing their use of resources.

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