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Study results confirm ability of T-SPOT®.TB to detect tuberculosis disease in HIV infected patients

Oxford Immunotec
6 Apr 2010

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Oxford Immunotec Ltd, the T cell measurement company, has today announced the outcome of a recent study performed at the Chelsea and Westminster Hospital, London.

The results of the study which were presented to the 12th Annual Conference of the British HIV Association meeting in Brighton (29th March-April 1st) confirmed that the Company’s T-SPOT.TB test is able to detect tuberculosis in HIV patients whose immune systems are severely compromised. These data confirm previously reported results from several other studies confirming that T-SPOT.TB performs well even in patients whose CD4 T cell count is less than 200 cells/ìl. The study also confirmed the ability of T-SPOT.TB to be used as a ‘rule-out’ test for TB infection in HIV patients.

Commenting on the reported findings, Peter Wrighton-Smith, Chief Executive Officer of Oxford Immunotec said “This study confirms previously published results by other groups and firmly establishes T-SPOT.TB as the only test for latent Tuberculosis infection to have consistently demonstrated efficacy in HIV infected patients with low CD4 T cell counts”.

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T-SPOT®.TB

Oxford Immunotec

The T-SPOT®.TB test is a revolutionary product that diagnoses both latent TB infection and active disease by measuring T cells that have been specifically activated by Mycobacterium tuberculosis (MTB) antigens. The T-SPOT.TB test sets new clinical standards of sensitivity and reliability. The product was licensed across Europe in July 2004 and received FDA premarket approval in July 2008. It has been designed to replace the current tuberculin skin test (Mantoux test), bringing effective TB testing to many new patient groups where the skin test gives poor or unreliable results. This revolutionary technology has been tested in many thousands of patients in all parts of the world. Studies have shown the excellent sensitivity and specificity of the T-SPOT.TB test and demonstrate its utility for the diagnosis and control of TB. The T-SPOT.TB kit is supplied with a plate containing 12 X 8 well strips. 4 wells are required for each patient sample

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ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.Clinical TrialsClinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. Clinical Trials are a phased process (Phase 0, Phase I, Phase II, Phase III and Phase IV) which begins after initial preclinical testing.

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Study results confirm ability of T-SPOT®.TB to detect tuberculosis disease in HIV infected patients