Solentim’s Cell Metric CLD™ Success in US Biopharma for Single Cell Cloning

Due to the significant time saving advantages of their Cell Metric™ systems, Solentim, a developer of innovative tools for shortening steps in the upstream cell line development workflow, have had their best quarter of sales revenues to date. This includes multiple shipments of Cell MetricTM systems to customers in the US and a repeat order from US biopharma.

Cell Metric CLD™ is a bench-top imaging station, which includes a 10 plate automated plate loader. The system addresses several key stages in the upstream cell line development workflow, including clone screening and documentation of monoclonality (for regulatory submissions), from either seeding single cells into 96 well plates with limited dilutions or by FACS sorting. The Cell Metric CLD™ also measures clone stability and growth rates by direct non-invasive cell counting in each well without having to remove a sample. Growth data can then be assessed with protein productivity measurements such as ELISA assay data in the same wells. In this way normalized protein productivity and titer can be calculated to identify and rank the best protein producers. The Cell Metric CLD™ is capable of detecting all cells, even immediately after seeding, affording a significant time advantage.

Automated clone imaging and screening have become a routine element of any new cell line development process. Cell Metric CLD™ has quickly become established as the market-leading clone imager with significantly better optics and automated detection capabilities than previous generation products. Aaron Figg, Managing Director of Solentim commented, “Customers have already reported substantial time savings of up to 3 months for a new cell line using the Cell Metric™ systems where the earlier and higher quality images have negated the need for further rounds of sub-cloning. The economic benefits of this are significant.”