Small Molecule Assay: 4-Carboxybenzenesulfonamide (201 Da) Binding to Carbonic Anhydrase II
21 May 2009Emily Marquez-Vega
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Carbonic anhydrase II (CAII) is an enzyme that catalyzes the reversible hydration of carbon dioxide to form bicarbonate with the release of a proton. 1 CAII activity is strongly inhibited by a variety of aromatic and heterocyclic sulfonamides. This application note presents the SPR binding experiment between CAII and an inhibitor, 4-carboxybenzenesulfonamide (4-CBS); a small molecule with a molecular weight of 201 Da.
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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.