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Silicon Biosystems Menarini, Swift Biosciences Announce Collaboration and CoMarketing Partnership to Unlock Genomic Information from FFPE Samples

Swift Biosciences, Inc

Alliance Combines the Power of Precise Single-Cell Isolation with Next Generation Sequencing

11 Feb 2016
Alex Waite
Editorial Assistant

Industry news

Silicon Biosystems Menarini Inc., a developer and manufacturer of technologies and products that help uncover the biological complexities of disease at the single-cell level, and Swift Biosciences Inc., a developer of innovative technologies for genomics research, today announced a scientific collaboration and co-marketing partnership aimed at enabling translational researchers to obtain high-quality sequencing results from as few as a couple hundred tumor and normal cells in an optimized and seamless workflow.

Silicon Biosystems Menarini will develop new workflows focused on translational research that combines its DEPArray™ System with Swift Biosciences’ Next Generation Sequencing (NGS) technology. The announcement was made at the annual Advances in Genome Biology and Technology (AGBT) meeting held in Orlando, February 10th-13th. Both companies will present recent findings of their collaborative research on February 13th.

Tim Harkins, CEO of Swift Biosciences, explained how the combination of the two technologies enables oncology researchers to fully access genomic information locked within formalin-fixed paraffin-embedded (FFPE) tissue samples. “Working with Silicon Biosystems Menarini has revolutionized the analysis of FFPE samples by enabling researchers to perform whole genome, exome and targeted resequencing from samples that previously could not be sequenced. There is a treasure trove of genetic information in countless FFPE collections that can now be unlocked with the combination of these technologies. It is a very exciting time for the oncology community.”

Giuseppe Giorgini, CEO of Silicon Biosystems Menarini added, “Offering our DEPArray system owners the simple and optimized sequencing solution that Swift Biosciences provides will guarantee them reliable and high-quality results that translational research requires.”

Combining the Power of Precise Single-Cell Isolation with NGS The DEPArray system is capable of isolating a few hundred matched tumor and normal cells from FFPE materials, or from frozen tumor specimens, and cell cultures. Based on the principle of dielectrophoresis, which exploits the ability of a non-uniform electric field to move cells in a spatial gradient, the system provides precise image-based cell selection for identification and sorting of individual cells, or pools of cells, at 100% purity for further genetic analysis or culturing. With Swift Biosciences’ Accel-NGS® 2S DNA Library Kits researchers are able to build complex libraries from as little as 100 pg of DNA. The new Accel-NGS 2S Hyb DNA Library Kit will allow the sequencing of whole exomes from FFPE samples that contain low amounts of damaged and fragmented DNA. The DEPArray System and Accel-Amplicon™ panels have also been optimized together to deliver somatic mutation detection in 56 clinically relevant oncology-related genes.

For more information, visit http://www.siliconbiosystems.com.

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Find the best electrophoresis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Sample ManagementSample management systems include sample storage devices such as freezers and plate storers, sample environment enclosures and sample organization, retrieval and sorter systems. Useful system features include high-throughput, automation, robotic arms, automated liquid handling and associated database systems. Accessories in sample management include barcode scanners, heat sealers and tubes.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Robotic WorkstationsRobotic workstations are automated platforms enabling the user to perform high-throughput, multi-application processes, from sample preparation tasks such as PCR set-up, DNA purification and NGS library preparation, to integrated sample prep and analysis workstations. Automation makes processes consistent, fast, precise and fully walk-away. Find the best robotic workstations in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Automation Supplies / AccessoriesAutomated accessories and consumables make lab processes fast, efficient and reliable. Useful automation accessories include microplate sealers, label printers and reagent reservoirs.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cancer DiagnosticsThere are a wide variety of diagnostic tests for cancer available, and this range continues to expand as our knowledge of cancer improves. Current diagnostic methods include biopsy, imaging and blood tests for known biomarkers. New methods in research development include liquid biopsies and cancer breathalyzers.Single Cell AnalysisSingle-cell analysis involves studying individual cells to gain insights into their behavior, gene expression, and function. This approach is valuable in cancer research, stem cell biology, and immunology. Explore single-cell analysis products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Single Cell GenomicsGenome SequencingGenome sequencing involves determining the complete DNA sequence of an organism's genome. It provides crucial information about genetic variations, mutations, and diseases. Advances in sequencing technologies, such as next-generation sequencing (NGS), have accelerated research in genomics, diagnostics, and personalized medicine. Explore genome sequencing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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Silicon Biosystems Menarini, Swift Biosciences Announce Collaboration and CoMarketing Partnership to Unlock Genomic Information from FFPE Samples