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Sigma<sup>®</sup> Launches Innovative ChIP Kit Technology For Epigenetic Research

Merck
15 Apr 2008

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Sigma-Aldrich today announced the launch of its Imprint™ Chromatin Immunoprecipitation Kit for epigenetic research. The Imprint™ ChIP Kit provides a complete solution for Chromatin Immunoprecipitation, including columns and reagents for DNA purification as well as an integrated protocol for ChIP DNA amplification with the GenomePlex® Whole Genome Amplification Kit. This flexible format allows for immunoprecipitation and purification of DNA from mammalian cells or tissue in a convenient microwell format.

ChIP is an innovative technology that enables scientists to investigate complex DNA-protein interactions in vivo, potentially increasing the speed and accuracy of disease research and drug discovery. The Imprint™ ChIP Kit provides researchers with rapid and accurate results, enabling high-throughput, same-day downstream analyses via quantitative PCR, MS-PCR, and DNA sequencing as well as DNA microarray. With the shortest protocol time and highest throughput capabilities on the market, the Imprint™ ChIP Kit, offers significant time and cost savings to epigenetic researchers.

"Sigma's Imprint™ ChIP Kit incorporates all of the requirements for Chromatin Immunoprecipitation procedures," said Tim Fleming, Director of Global Commercial Marketing for Sigma-Aldrich Life Science. "These integrated tools will help researchers better understand complex protein networks and expedite epigenetic research and development."

The Imprint™ ChIP Kit complements Sigma Life Science's robust product line to support the epigenetic workflow, including the Imprint™ DNA Modification Kit as well as products for DNA purification, qPCR, sequencing and post-reaction clean-up. The Imprint™ ChIP Kit is based on Chromatin Immunoprecipitation (ChIP) technology licensed from Epigentek Group.

"This arrangement reinforces Epigentek's leading position in the epigenetic arena," said Adam Li, Chief Scientific Officer for Epigentek. "We share Sigma's commitment to developing the next generation of research tools for epigenetic research."

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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Sigma<sup>®</sup> Launches Innovative ChIP Kit Technology For Epigenetic Research