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Sigma-Aldrich Signs Exclusive Agreement to Commercialize Transplex™ Whole Transcriptome Amplification Technology

Merck
15 Dec 2006

Product news

Sigma-Aldrich is pleased to announce an exclusive licensing agreement with Rubicon Genomics to further develop and commercialize their TransPlex™ Whole Transcriptome Amplification (WTA) technology.

The TransPlex technology is the fastest, most sensitive and robust method available for amplifying total RNA from a variety of sample sources such as animals, plants, and microorganisms. Under the terms of the agreement, Rubicon retains all rights to TransPlex for molecular diagnostics.

"We are excited to have this opportunity to expand our relationship with Rubicon," said Keith Jolliff, Director of Marketing for Genomics and Functional Genomics. "Sigma-Aldrich is committed to bringing best-in-class- technologies to the genomic research community, and the TransPlex™ Whole Transcriptome Amplification kit is clearly in that category."

John Langmore, VP of Commercial Development at Rubicon, said: "Rubicon is very pleased that Sigma-Aldrich will be marketing TransPlex kits to complement the very successful GenomePlex® Whole Genome Amplification kits. We have confidence that their customers will embrace TransPlex for biological research and development of diagnostic products."

TransPlex WTA creates a cDNA library from the isolated RNA template and then amplifies the library in a single PCR reaction. The TransPlex reagents and protocols, optimized to ensure a linear representation of all expressed genes and exons, allow RNA samples to be amplified 1,000-10,000 fold in less than four hours. This technology is highly robust and works well even when the RNA is partially degraded, as in formalin-fixed paraffin-embedded tissue.

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Compound LibrariesCompound libraries, or chemical libraries, are used in drug discovery for the identification of potential therapeutics compounds. Used in conjunction with high-throughput screening, the libraries of stored compounds are often generated for specific purposes as a drug target or disease model. Cheminformatics are commonly used when designing a compound library and software can be used to analyze the screening process.  DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.

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