Shimadzu’s New Nexera Ultra High-Performance Liquid Chromatograph Delivers High-Speed and High-Resolution Analysis

Shimadzu Scientific Instruments introduces the Nexera ultra high-performance liquid chromatography (UHPLC) system, which delivers high-speed and high-resolution analysis without sacrificing basic performance parameters such as excellent precision, near-zero carryover, good linearity, stability and ruggedness. Offering these attributes enables Nexera to provide superior performance in various fields, covering high-resolution and high-speed separation, as well as high-sensitivity detection.

Shimadzu’s Nexera is optimized to enable analysis at pressures up to 130 MPa. Without compromising performance and data quality, the maximized pressure over a wide flow range enables various types of analyses, including micro LC to conventional LC, regular pressure LC to ultra high-pressure LC, and isocratic LC to ternary high-pressure gradient and multi-dimensional LC. The system is also suitable for LC-MS applications.

Nexera’s fast injection — just 10 seconds — enables fast chromatography to shorten cycle time and result in true high throughput with 4,600+ sample capacity. Nexera’s newly designed injection port and fine-tipped needle, along with additional features such as multiple-rinse solvent selection and injection port and internal needle rinse, reduce carryover to an absolute minimum.

The autosampler also offers fixed-loop injection for ultra-fast separation with minimized peak width and gradient delay. An overlapping injection function is standard with Nexera to allow for a maximum reduction in cycle time.

For high-temperature LC analysis, Nexera offers efficient pre-heating for solvents to enable stable and reliable conditions. The advanced Intelligent Heat Balancer (IHB) minimizes band broadening during high-temperature analysis through the use of independently controlled heat zones within the column compartment, ensuring accurate column temperature regardless of flow rate. The post-column cooler can reduce detector noise when equipped for high-temperature analysis up to 150oC.

“At Shimadzu, our passion has always been to improve performance, ease of use and flexibility for all HPLC environments,” said Shuzo Maruyama, General Manager of LC Business Unit. “That passion continues with Nexera, the only no compromise UHPLC system to offer the reliability, versatility, and superior basic performance for all applications.”