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Shimadzu’s New LC/MS/MS Method Package for Primary Metabolites Enables Fast, Simultaneous Analysis of 55 Primary Metabolites

Shimadzu Corporation
16 Jun 2013
Sarah Thomas
Associate Editor

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Shimadzu has introduced its Method Package for Primary Metabolites, designed for the simultaneous analysis of a variety of metabolites associated with central metabolic pathways.

Unlike current techniques, such as CE/MS, derivatization followed by GC/MS, or HILIC LC/MS, Shimadzu’s new LC/MS/MS Method Package for Primary Metabolites allows simultaneous analysis of a wider range of compounds. It permits high-throughput simultaneous analysis of 55 primary metabolites in a single 20-minute injection using ion-pair chromatography coupled to LC/MS/MS analysis. The compound panel includes primary metabolites associated with the glycolytic system, the TCA cycle, and the pentose phosphate pathway as well as amino acids and nucleotides.

The LC/MS/MS Method Package for Primary Metabolites also includes biological tissue sample preparation protocols that are applicable to LC/MS/MS. In addition, the inclusion of two internal standards allows for normalization of results.

Disclaimer: For Research Use Only. Not for Use in Diagnostic Procedures.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. MetabolitesMetabolites are the intermediate and end products of metabolism. Analyzing metabolites offers insight into cellular processes and disease mechanisms and is critical in fields like pharmacology, toxicology, and diagnostics. Explore our peer-reviewed product directory to find the best tools for metabolite analysis, compare products, check reviews, and get pricing directly from manufacturers.MetabolomicsMetabolomics is the study of small metabolites (the intermediates and products of metabolism). It involves the identification and quantification of cellular metabolites using analytical technologies such as GC, HPLC, NMR, and LC/MS.ASMSThe American Society for Mass Spectrometry (ASMS) is an organization dedicated to advancing the science and application of mass spectrometry. ASMS supports professionals through events, publications, and research initiatives, promoting innovation in areas like proteomics, metabolomics, and environmental analysis.

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Shimadzu’s New LC/MS/MS Method Package for Primary Metabolites Enables Fast, Simultaneous Analysis of 55 Primary Metabolites