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Shimadzu and Indigo BioSystems Partner to Leverage the Power of ASCENT™ Clinical Solutions on Ultra-Fast Mass Spectrometry Platforms

Shimadzu Corporation
17 Jun 2014
Sarah Thomas
Associate Editor

Product news

Shimadzu and Indigo BioSystems have announced a partnership to develop and market mass spectrometry solutions that simplify and accelerate clinical data acquisition and data review for applications in clinical research, forensic toxicology and new drug development.

Under the terms of the agreement, Shimadzu is combining its ultra-fast mass spectrometry platforms with Indigo BioSystems's expert system software. ASCENTTM clinical analysis software is a comprehensive and powerful data analysis suite that interprets visual data results from instruments and automatically reviews the data for problematic results. Results are delivered quickly, consistently, and reliably.

ASCENT supports the scientist by automatically analyzing and reporting correct data, and flagging only the outliers for expert review. ASCENT™ speeds sample analysis by automating peak selection and peak area fitting. ASCENT also includes assay-specific quality assurance rules, which allow peaks to be automatically tested for quality. ASCENT operates using a web-browser interface requiring no software to be installed on computers in order to perform quantitative analysis.

Patrick Armstrong, Director of Shimadzu Scientific Instrument’s R&D department said, “Indigo BioSystems’ tools for high-throughput, automated data analysis are highly developed with an impressive list of advanced features, and greatly simplify clinical laboratory workflows,” adding that, “We are excited to work with Indigo to leverage powerful ASCENT™ tools on Shimadzu ultra-fast mass spectrometry platforms”.

Dr. Randall Julian, CEO of Indigo BioSystems said, “Our partnership with Shimadzu will result in tighter integration between their excellent ultra-fast LC-MS/MS and our automated analysis software ASCENT. This collaboration allows production labs to achieve maximum efficiency, superior quality, and rapid turnaround time. Shimadzu instruments, in combination with the ASCENT software, create a high-throughput, intelligent, production system.”

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.Clinical TrialsClinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. Clinical Trials are a phased process (Phase 0, Phase I, Phase II, Phase III and Phase IV) which begins after initial preclinical testing.Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.Forensic ToxicologyForensic toxicology is used to determine cause of death, drug use and contaminations. Toxicological evaluations are commonly used in analytical chemistry, clinical, life sciences and forensics.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.

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Shimadzu and Indigo BioSystems Partner to Leverage the Power of ASCENT™ Clinical Solutions on Ultra-Fast Mass Spectrometry Platforms