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Seegene and Selventa form Strategic Collaboration to Develop Novel Molecular Diagnostics (MoDx)

23 Apr 2013
Sarah Thomas
Associate Editor

Product news

Seegene and Selventa announced that they have entered into a strategic collaboration to develop novel molecular diagnostics in underserved diagnostic markets including autoimmune, cancer and infectious diseases. The synergistic combination of Selventa's Systems Diagnostics (SysDx™) multi-omic analytics platform and Seegene's TOCE™ and DPO™ multiplex PCR technology will result in powerful new MoDx that accelerate the adoption of personalized medicine in major classes of disease.

Selventa' SysDx works by analyzing a holistic range of a patient's molecular information (e.g., genomic, epigenomic, transcriptomic, proteomic, metabolomic, and electronic medical record information) to identify a panel of "multi-omic" biomarkers that can accurately diagnose a patient's disease and response or non-response to a therapy. By leveraging a powerful, first-in-class multiplexing technology, SysDx's multi-omic biomarker approach can be the basis for a range of high value MoDx.

Seegene's qTOCE technology provides real-time simultaneous detection and quantification of multiple targets in a single channel ("one channel - many targets"). qTOCE can work with any qPCR instrument to differentiate as many as 7 targets per channel from a single sample, in a single reaction. qTOCE enables multiplex assay development across a wide range of applications, including high-multiplex quantitative real-time PCR and highly selective mutational analysis.

"We are excited to collaborate with Seegene, a leading molecular diagnostic technology innovator," said Dr. David de Graaf, President and CEO, Selventa. "Seegene's world-class detection technology and assay development in combination with our SysDx platform can result in a wide range of novel MoDx with high clinical utility."

"Selventa's SysDx platform is a breakthrough approach to biomarker identification that has the potential to vastly improve patient diagnosis and care," said Dr. Jong-Yoon Chun, founder, CTO and CEO of Seegene. "Our multiplex PCR technology detecting a wide range of SysDx-derived biomarkers can facilitate better patient diagnostics, improved patient care, and reduced healthcare costs."

About System Diagnostics (SysDx)
SysDx testing is a much needed progression from 'single-omic' tests that today are largely limited to the analyses of genetic aberrations in a patient's disease. As the molecular drivers of disease are intertwined across thousands of interrelated biochemical pathways, it is vital that a diagnostic be able to test for a more comprehensive set of disease-relevant biomarkers. SysDx testing promises to capture a more detailed profile of a patient's disease leading to superior predictive and prognostic healthcare decisions

About DPO and TOCE technologies
DPO™ technology is a fundamental tool for blocking extension of non-specifically primed templates generating consistently high specificity. TOCE enables simultaneous multiple assay testing, by separating genes (that have been amplified with the real-time PCR technology) using the differences in their melting temperatures. Prior to TOCE, multiple assays were difficult because even a small variation in the amplified gene sequence changes the melting temperature of the genes; and reduces the number of fluorescent signals that can be tested at the same time, due to fluorescent intervention among amplified genes. TOCE technology overcomes these limitations. It allows testing of multiple pathogens with one fluorescent material by ensuring that sequence variation does not change the melting temperature of the genes.

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Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Clinical MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Molecular BiologyMolecular biology is the branch of biology that focuses on the molecular mechanisms that underlie cellular functions. It involves studying DNA, RNA, and proteins to understand gene expression, replication, and regulation. Molecular biology is fundamental to biotechnology, medicine, and genetic research. Explore molecular biology products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.qPCRQuantitative PCR (qPCR) is a molecular biology technique used to amplify and measure the amount of a specific DNA or RNA target. It plays a crucial role in gene expression analysis, pathogen detection, and quantifying DNA or RNA in various applications. Real-time PCR provides precise, quantitative results and is widely used in research, diagnostics, and clinical studies. Browse our peer-reviewed product directory to find the best qPCR solutions; compare products, check reviews, and get pricing directly from manufacturers.Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.

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Seegene and Selventa form Strategic Collaboration to Develop Novel Molecular Diagnostics (MoDx)