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SCIEX Launches New M3 MicroLC System

SCIEX

First SCIEX liquid chromatography system developed for sensitivity, ease of use and throughput in bioanalytical labs

25 Nov 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Product news

SCIEX, a global leader in life science analytical technologies, has introduced the M3 MicroLC System, a new fully-integrated micro-scale LC system designed for biopharmaceutical applications such as antibody drug development, where sample size is limited. The M3 MicroLC System improves the sensitivity of LC-MS workflows, enabling researchers to reach lower limits of quantitation in their bioanalysis lab, without sacrificing throughput. With the M3 MicroLC System, customers will now be able to run up to 200 samples per day, on a continuous basis.

The M3 MicroLC System is designed for scientists who are struggling to analyze small volume samples with conventional LC-MS and need to lower their limits of quantitation while maintaining throughput and robustness. The M3 MicroLC platform offers the option of a new microflow trap-and-elute capability that allows labs to analyze analytical-scale sample volumes on a micro-scale LC-MS.

"Micro-scale LC-MS has traditionally increased sensitivity and reduced sample consumption for our customers, but with it came tradeoffs in flexibility and throughput," said John Plohetski, Global Vice President, Separations at SCIEX. "With its micro-scale efficiency and trap-elute capability, our new M3 MicroLC system enables researchers to significantly lower the level of quantitation and still have the advantage of both sensitivity and throughput, leading to consistently accurate results."

Smartly designed, the benchtop system can sit side-by-side or stacked on top of the Mass Spec for optimal use of available laboratory space. The SCIEX M3 MicroLC System has been developed for the sensitivity, ease of use, and throughput needs of biopharmaceutical development and delivers:

  • Micro flow LC improves LLOQs up to 10x
  • High throughput while increasing sensitivity
  • Up to 90% solvent savings leading to a lower cost of analysis
  • State-of-the-art control via SCIEX Analyst Software that support 21 CFR Part 11 compliance

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.NanoLCNano LC is a nano scale liquid chromatography technique typically used for proteomic applications. The nano refers to the very low flow rate of the mobile phase in the system. The advantage of nanoLC is its high sensitivity. Often the system is integrated with a mass spectrometer in nano LC-MS or nano LC-MS/MS. When using nanoLC equipment consider column choice, software and accurate and precise flow rate control.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.High ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.BiotherapeuticsBiotherapeutics are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or in <i>in vivo</i> diagnostics. The most well-known example of a biotherapeutic product, and the first to be approved for therapeutic use, was recombinant human insulin.

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