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Scaling Up Screening in 96- & 384-Well Microplates

INTEGRA Biosciences
8 Dec 2015
Lois Manton-O'Byrne, PhD
Executive Editor

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INTEGRA reports on how researchers at the Health Innovation Research Institute at RMIT University are using VIAFLO II electronic pipettes in conjunction with a VIAFLO ASSIST to scale-up their screening of venoms and small compounds.

The Health Innovations Research Institute (HIRi) is an RMIT University initiative that seeks to address key health issues facing Australia in the 21st century, with research programs that examine how the human body functions at a molecular and cellular level. This research is targeted to provide innovative therapeutic strategies to improve the health and wellbeing of people in Australia and around the world.

Bill Darby, a Researcher at HIRi, commented "We approached INTEGRA’s Australian distributor (BioTools Pty Ltd.) for a solution to scale-up our screening of venoms and small compounds in both 96- and 384-well plates. Following a demonstration, we found that the VIAFLO ASSIST pipetting assistant met our required criteria of a cost effective and easy to use pipetting solution, which lead us to purchase the ASSIST and 3 VIAFLO II multichannel pipettes”.

Mr Darby added “Since its introduction, the system has been running perfectly and we have been able to achieve the scaling-up we required. The ASSIST has delivered more accurate and precise pipetting results that have improved our assay results. Another significant benefit is that the ASSIST is very compact and easily fits in our lab hood. We have also found that the versatility of the VIAFLO II pipettes has proven especially useful for handling complicated layouts in 384-well plates”.

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VIAFLO Electronic Pipettes

INTEGRA Biosciences

Electronic pipettes with touch wheel user interface.   VIAFLO pipettes accommodate any pipetting task at hand: from single transfers to complex protocols. An intuitive touch wheel interface and color display allows for the quickest volume changes and user friendly menu navigation. The ergonomic design enables effortless pipetting. The unique tip fitting of the VIAFLO pipette assures that GripTip pipette tips will never loosen, leak or fall off. VIAFLO Electronic Pipettes Features:   GripTip Pipette Tips - By designing our GripTips™ in tandem with VIAFLO pipettes, we have created a unique, integrated system that offers the securest pipette and pipette tip connection. High lateral resistance. This prevents tips from falling off when touching off a multichannel pipette within a 96 or 384 well plate. Low required tip attachment forces. Low required tip ejection forces. All tips seal at the same height ensuring a perfect touch off and increased precision when dispensing. Intuitive User Interface - A full color screen and a proven touch wheel interface offer quick and comprehensible menu navigation. Simply by moving a finger over the touch wheel, menus and settings can be accessed. All menus are spelled out on the clear to read screen making memorizing of abbreviations unnecessary. Convenient Pipette and Program Management - VIAFLO pipettes can be connected to a computer via USB port. With the free to use pipette management software VIALINK, custom programs can be created on the computer and then be transferred onto VIAFLO pipettes. For laboratories with many users or power users with many pipetting protocols, all custom programs can be stored and backed up in a library on the computer. Applications: Repeat Dispense Manual Pipetting Sample Dilution Reverse Pipetting Variable Dispense

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MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.Assay DevelopmentThe process of proving an assay to be sensitive with respect to the target is known as assay development. The assay should be able to characterize novel compounds and measure the potency of these compounds against a validated biological target.Electronic PipetteElectronic pipettes are precision instruments used to transfer measured volumes of liquid in laboratory settings. They offer high accuracy, ease of use, and ergonomic benefits compared to traditional pipettes, reducing the risk of repetitive strain injuries. Electronic pipettes are widely used in molecular biology, chemistry, and diagnostics. Browse our peer-reviewed product directory to find the best electronic pipettes; compare products, check reviews, and get pricing directly from manufacturers.Molecular DiagnosticsMolecular diagnostics use an individual’s genetic code and gene expression to diagnose and monitor diseases. The technique is used increasingly in the field of infectious diseases and oncology, as well as areas such as coagulation, HLA typing and pharmacogenomics. Molecular diagnostics plays a pivotal role in personalized medicine.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.TherapeuticsTherapeutics are treatments designed to alleviate or cure diseases. These include pharmaceuticals, biologics, and gene therapies, which work by targeting specific disease mechanisms. Advances in personalized medicine and biologics offer new hope for patients with conditions that were previously difficult to treat. Browse our peer-reviewed product directory to find therapeutic solutions for various diseases; compare products, check user reviews, and get pricing directly from manufacturers.

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