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Sartorius releases the 4th edition of its popular live-cell analysis handbook

Sartorius Group

A comprehensive and interactive digital guide, to real-time live-cell imaging and analysis

15 Sept 2020
Sophie Ball
Publishing / Media

Industry news

Sartorius, a pioneer in new technologies for real-time live-cell imaging and analysis, has released the 4th edition of its Live-Cell Analysis Handbook. The handbook was first launched in 2017 as a comprehensive reference guide for live-cell analysis technologies, with a focus on the complete suite of Incucyte® live-cell assays and reagents. The handbook has been well received by Incucyte® users, generating over 2,500 requests of its 3rd edition.

The live-cell applications covered in the handbook include cell culture quality control assays and kinetic assays for cell health, proliferation, and viability; cell migration and invasion, protein dynamics, complex cell models; and neuronal models. The 4th edition includes new sections on assays for evaluating Organoid Culture QC, ATP Metabolism, and Cell Cycle. Additionally, there is a new chapter on kinetic assays for immune cell health and function.

“This new edition truly encompasses the broad range of assays that can be accomplished across multiple therapeutic areas, allowing scientists to push the boundaries of cell-based assays. Of particular interest in this edition are assays using live-cell indicators, such as CytoATP, for direct quantification of dynamic ATP changes in complex co-culture models. With our unique assay, combining instrumentation, hardware and reagents, we are able to evaluate nutrient exchange between tumor and stromal cells, which can mediate resistance to metabolically-targeted treatments,” said Lindy O’Clair, Head of BioA Applications, Reagents and Consumables. “Giving scientists the tools they need to streamline their research and gain deeper biological insights, across a range of assay models, is imperative to driving novel advances in science.”

The Incucyte® Live-Cell Analysis System allows for real-time, uninterrupted monitoring of a range of cell types, from proliferating tumor cells to sensitive primary cells. Validated Incucyte® live-cell assays, reagents and protocols, allow scientists to explore questions across a range of applications and research fields, without the limitations of end point assays. The handbook is written by Sartorius scientists and product managers, and updated yearly to include the newest offerings.

To download the free 4th Edition Live-Cell Analysis Handbook, click here.

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Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.In Vivo Imaging Systems<i>In vivo</i> imaging systems, including pre-clinical imaging systems and medical imaging systems are used to non-invasively visualize and capture images of live animals and plants. Monitor the natural processes or diseases of your subjects using small-animal pre-clinical imaging systems, including single photon positron emission tomography (SPECT), positron emission tomography (PET), computed tomography (micro-CT), magnetic resonance imaging (MRI), X-ray radiography, ultrasound, fluorescence and bioluminescence imagers. Multimodal systems and software solutions are also available for correlative analysis of organ, tissue, cell, or molecular-level processes. Find the best in vivo imaging products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell AnalysisThe analysis of cells allows researchers to understand the factors which contribute to cell health and function. These influencing processes can then be predicted and altered, leading to the development of medication and disease treatments.Live Cell ImagingLive cell imaging is the study of living cells using microscopes and high-content imaging systems. This technique provides in-depth insight into fast and complex biological processes, by allowing dynamic imaging of living cells instead of acquiring an individual image at a single point in time.

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