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SARS-CoV-2 antibodies and antigens for diagnostic kit development

AMSBIO
18 Oct 2020
Edward Carter
Publishing / Media

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AMSBIO has further expanded its product range to help in the fight against COVID-19 with the introduction of a new range of SARS-CoV-2 antibodies and antigens to aid the development of new immunoassay diagnostic kits.

While RT-PCR diagnostic kits has provided fast and sensitive COVID-19 case confirmation, the technique suffers from some inherent drawbacks that limit it to diagnosis during the acute phase of infection. To facilitate rapid screening and instant detection of SARS-CoV-2 infection, development of faster and convenient antibody and antigen-based immunoassays are essential. However, the sensitivity and specificity of these serological diagnostic kits will be significantly affected by the quality of antigen and antibody reagents used to make them.

A suite of SARS-CoV-2 mutant spike and nucleocapsid antigens is now available from AMSBIO. Perfect for use in a wide range of different antibody detection methods, these antigens are customizable and available in bulk. In addition, AMSBIO has also introduced a new range of matched antibody pairs that were specifically designed and screened for antigen detection kit development. Verified against inactivated COVID-19 virus samples, these antibody pairs are ideal for development of diagnostic assays including chemiluminescent immunoassay, ELISA and gold immunochromatography (also known as lateral flow). The sensitivity of these matched antibody pairs used in a sandwich ELISA kit has been shown to be as low as 12pg/mL. The virus titer, which was determined using a LFA assay, is as low as 102CCID50.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Molecular DiagnosticsMolecular diagnostics use an individual’s genetic code and gene expression to diagnose and monitor diseases. The technique is used increasingly in the field of infectious diseases and oncology, as well as areas such as coagulation, HLA typing and pharmacogenomics. Molecular diagnostics plays a pivotal role in personalized medicine.CoronavirusCoronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases like COVID-19. Research into the biology, transmission, and treatment of coronaviruses has become a global priority, particularly since the emergence of SARS-CoV-2. Understanding the virus�s structure and behavior is essential for developing vaccines, diagnostics, and antiviral treatments. Explore our peer-reviewed product directory to discover the latest research tools, diagnostic tests, vaccines, and treatments for coronavirus, compare products, read reviews, and receive pricing directly from manufacturers.Covid-19COVID-19, caused by the SARS-CoV-2 virus, has led to a global health crisis with profound impacts on societies and economies. Research into diagnostics, vaccines, treatments, and understanding viral mechanisms continues to evolve. The pandemic has accelerated innovations in healthcare and biopharmaceuticals, including novel vaccine platforms and rapid testing technologies. Browse our peer-reviewed product directory to find top COVID-19 testing kits, research tools, vaccines, and treatments, compare products, read reviews, and receive direct pricing from manufacturers.

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