RTS Introduces SmaRTScreen

3 Jul 2007

Product news

OVER the last five years, the RTS Life Science Assay Platform has become a highly respected, market leading system in High Throughput Screening. However, customer feedback has revealed a need for a smaller, standardised, lower cost version with much shorter lead times.

David Harding, technical director for RTS, and part of the original team behind Assay Platform, explained: “Our customer feedback has shown that many pharma departments, particularly early ADMETox, Assay Development and Lead Optimisation, need a simple, compact, flexible automated alternative to manual assaying. SmaRTScreen delivers this and thanks to our versatile Sprint scheduling software, it can also offer plate replication and small scale cell culturing.”

Sprint not only future-proofs SmaRTScreen by allowing instruments to be replaced as they are superseded, but sub groups of instruments can be created, allowing specific instruments to be chosen for an allotted task, greatly enhancing its flexibility. All of the ‘full’ Assay Platform functionality is preserved, giving the user big system performance and for a small system price and lead-time.

Although the system has not been formally launched, such is the interest in the smaller sibling of the Assay Platform, that one has already been sold and there are several more sales in the pipeline. Like its bespoke counterpart, SmaRTScreen will feature three distinct functions: storage and incubation, liquid handling and plate reading. However the instruments in SmaRTScreen are typically served by a smaller robot, typically a Staubli TX40, as a result, the entire system footprint can be as low as 2m2.

Phil Eeles, business unit manager – Platform Solutions, said: “Thanks to Sprint, we can offer our customers tremendous flexibility, because we can add more instruments and easily shift them around within a compact table top arrangement. We are able to offer a 50% reduction in our standard lead time and SmaRTScreen costs just 60-70% the price of the Assay Platform, depending on the instruments chosen.”

A typical SmaRTScreen configuration features a storage device, a liquid or reagent dispenser, a transfer device or liquid handler, some waste bins and a small reader. If a larger reader, like a FLIPR Tetra is required, this can be docked onto the System externally.

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.