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Routine DART®-MS analysis of low solubility, high molecular weight compounds

Bio Chromato, Inc.

The ionRocket sample preparation device enables routine analysis in conjunction with DART-MS

4 Jan 2022
Rory Shadbolt
Publishing / Media

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BioChromato Inc. reports how their ionRocket sample preparation device, used in combination with Direct Analysis in Real Time Mass Spectrometry (DART®-MS), enables routine analysis of low solubility, high molecular weight compounds.

Phthalocyanine-based pigments are widely used for organic semiconductors and organic electroluminescence displays due to their clearness, high light stability, and durability. However, the chemical structure of Phthalocyanine based pigments is difficult to analyze due to their high molecular weight and low solubility. The application report provides data illustrating how DART®-MS with ionRocket sample introduction enabled structural information to be determined concisely and rapidly. The analysis was done under atmospheric conditions and without pre-treatment.

The BioChromato ionRocket is a temperature-heating device for direct thermal desorption and pyrolysis of samples, prior to ionization and analysis by mass spectrometry. Using ionRocket a temperature gradient from ambient up to 600ºC can be achieved in just a few minutes. This enables insoluble, high molecular weight materials to be pyrolyzed and then introduced into the DART®-MS gas stream.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Molecular Weight AnalysisMolecular weight analysis determines the size and structure of biomolecules, essential in protein characterization, polymer studies, and drug development. Techniques like mass spectrometry ensure precise results. Compare solutions for molecular weight analysis in our peer-reviewed product directory.Organic CompoundsOrganic compounds are carbon-based molecules that form the building blocks of life. These include hydrocarbons, lipids, proteins, and nucleic acids. Understanding organic compounds is crucial in chemistry, biochemistry, and pharmacology. Explore organic compound analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.SemiconductorsLuminescenceLuminescence techniques detect and measure light emitted by substances during chemical reactions or biological processes. Widely used in assays for diagnostics, environmental monitoring, and drug screening, luminescence-based methods offer high sensitivity. Explore leading systems and products in our directory.

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