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Roche's xCELLigence System: First Cell Analyzer System Installed at AgenoLab in Stuttgart

12 Aug 2008

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On April 3rd, three months before worldwide launch, Roche Applied Science sold the first xCELLigence System at the Analytica 2008 trade in Munich. In July the system has been installed at AgenoLab GmbH & Co. KG in Stuttgart (Germany), a supplier of contract biotechnology and life science laboratory services. AgenoLab is the first company worldwide using the new technology of Roche Applied Science for real-time cell monitoring. Also the company uses the latest LightCycler 480 instrument for real-time PCR analysis. AgenoLab offers worldwide services in GMP production, microbiology, molecular biology, cell culture technology, tissue engineering, quality assurance, oncology, and histology.

The cell-based xCELLigence System was originally invented by US-based ACEA Biosciences, and co-developed by Roche and ACEA. The xCELLigence System will be marketed exclusively by Roche on a worldwide basis. The design of the electronic sensor and other innovative techniques to collect and assess data make this system an excellent platform for cell-based assays and provide a benchmark potential for cellular and molecular biology. Continuous measurement is performed label free and fast – the system needs less than 15 seconds to analyze a 96 well E Plate.

“The fact that the first xCELLigence Systems have already been ordered before the official product launch shows that there is a real need for this new technology in cell analysis,” states Manfred Baier, Head of Roche Applied Science.

For more information on the technology of the xCELLigence System, please visit the article webpage.

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.

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Roche's xCELLigence System: First Cell Analyzer System Installed at AgenoLab in Stuttgart