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Roche launches first in vitro diagnostic IHC test to detect ROS1 protein in cancers

The VENTANA ROS1 (SP384) rabbit monoclonal primary antibody is designed to effectively identify elevated ROS1 protein expression

12 Aug 2019
Charlie Carter
Life Sciences Editor

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Roche has announced the global launch of the VENTANA ROS1 (SP384) rabbit monoclonal primary antibody, the first and only in vitro diagnostic ROS1 immunohistochemistry (IHC) assay. The test is designed to detect the presence of ROS1 protein in tissue, and may be useful in identifying ROS1-positive cancer cases. Guidelines from the College of American Pathologists and the National Comprehensive Cancer Network recommend ROS1 testing for confirmed lung adenocarcinoma cases.

As these types of cancer are rare, found in up to 2% of non-small cell lung cancer cases, the use of a ROS1 IHC biomarker may provide a cost-effective and efficient means of identifying cases with elevated ROS1 protein expression before confirming by another method, such as by fluorescence in situ hybridization (FISH) or next-generation sequencing.

“Our highly sensitive ROS1 test is the first in vitro diagnostic IHC available for recommended lung cancer testing guidelines, with the added benefit of rapid turnaround time," said Jill German, Head of Roche Tissue Diagnostics. “While this is important in non-small cell lung cancer cases today, ROS1 is also being investigated in a number of clinical trials in other cancer types.”

The VENTANA ROS1 (SP384) rabbit monoclonal primary antibody is a US class I/CE in vitro diagnostic device and is available for use on Roche’s BenchMark series of automated staining instruments.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.AACCThe American Association for Clinical Chemistry (AACC) Annual Meeting and Clinical Lab Expo is the largest meeting for clinical laboratory professionals in the world. This year's meeting is being held in Atlanta, USA, July 26th-30th, 2015.Lung CancerLung cancer is a leading cause of cancer-related deaths worldwide, often diagnosed at an advanced stage. Research focuses on early detection, targeted therapies, and personalized treatment strategies. Explore lung cancer research and diagnostic products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.

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Roche launches first in vitro diagnostic IHC test to detect ROS1 protein in cancers