Resolve Biosciences and ZEISS announce co-development collaboration to enhance highest-resolution view of subcellular spatial biology

Resolve Biosciences, the pioneer in Molecular Cartography™, and ZEISS have announced a co-development collaboration to advance spatial biology applications. The companies are working together to optimize advanced microscopy and 3D imaging solutions for subcellular spatial analysis. ZEISS microscopy technology is part of Resolve’s current Molecular Cartography service offering and will be incorporated into the commercial spatial transcriptomics system scheduled to launch later this year.

Resolve’s Molecular Cartography platform enables scientists to resolve the most complex biological challenges in areas such as oncology, neuroscience and infectious disease. Through this collaboration, ZEISS and Resolve Biosciences will combine leading optical technologies and engineering expertise with multi-analyte and highly multiplexed spatial analysis to illuminate molecular interactions at subcellular resolution while preserving the sample tissue. The companies will work together to enhance the Molecular Cartography workflow through the development of novel optical systems and computational approaches.

“This collaboration with Resolve Biosciences will enable scientists to achieve the highest-quality results in an integrated workflow with optimized throughput,” said Michael Albiez, Head of ZEISS Research Microscopy Solutions. “As the next frontier of biological research, spatial analysis presents the perfect opportunity to apply our advanced microscopy solutions for the clearest view of biological systems. We are committed to working with the Resolve team to allow more researchers to gain new insights in subcellular spatial biology.”

Resolve’s Molecular Cartography platform has been under development since 2016 and is currently available through a commercial service offering to researchers in Europe and North America. Unlike other current approaches, the Resolve platform provides the required sensitivity, specificity and workflow convenience to elucidate a cell’s complex transcriptional landscape. The technology produces deep contextual data sets that illuminate molecular interactions at subcellular resolution while preserving the sample tissue. Resolve’s Molecular Cartography platform currently delivers the highest-resolution view of transcriptomic activity and provides the ability to interrogate hundreds of genes in a single run. Future iterations of the technology will add DNA, protein and metabolomic data layers.

“Through this alliance, we now have access to key resources to scale our services business and are well on our way to providing our customers with a complete commercial system that features the latest advances in German precision engineering,” said Jason T. Gammack, Co-founder and CEO of Resolve Biosciences.

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