Reinnervate Launcews Alvetex®: Enabling Routine 3D Cell Culture

22 Nov 2010
bridget bridget
Laboratory Director

Product news

Reinnervate, an innovative life sciences company driving the adoption of routine 3D cell culture, is very pleased to announce today the first commercial launch of alvetex®, its breakthrough 3D cell culture technology.

Alvetex® is a unique material that provides a robust and inert scaffold for cells to grow and form complex 3D cell structures in the laboratory, mimicking the normal growth and formation of tissues in the body.

Reinnervate has extensively tested and validated alvetex® with a large number of cell types, including liver, skin, cancer and stem cells, all of which have important applications in basic research into cell development, disease modelling and drug safety screening.

The first alvetex® format to be launched is a 12 well plate (see picture) designed as an off-the-shelf, sterile-packed and ready-to-use product and will be available via international life science product distributors. Alvetex®, seen as a white membrane at the bottom of each well, has a highly porous architecture that is specifically tailored for 3D cell culture and is compatible with a large number of well-known cellular and molecular assay techniques.

The Company plans over the next 12-18 months to introduce alvetex® products in a range of standard multi-well plates including those suitable for high-throughput drug screening, and unique well inserts that enable long-term 3D cell culture over several weeks. Alvetex® is designed and developed with the needs of cell biologists in mind and will allow researchers in academia and the pharmaceutical and related industries to construct different 3D cell culture models to meet their specific research needs.

Ashley Cooper, CEO of reinnervate, said: “There is a real need for a technology that can allow the routine generation of genuine 3D cell cultures in the laboratory. This need is being reflected in the considerable level of interest being expressed by international life sciences products companies to distribute alvetex® products. The first commercial launch of this innovate product is a great achievement for all involved in its development at reinnervate and many congratulations are deserved.”

Professor Stefan Przyborski, reinnervate’s Chief Scientific Officer and founder, said: “We are extremely proud to launch alvetex® following the intense development efforts of our innovative and highly dedicated team. We believe we have created a truly game-changing technology for which there is huge demand, and that will enable rapid and important advances in our understanding of cell behaviour and ultimately lead to novel therapeutic approaches.”

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :
Reinnervate Launcews Alvetex®: Enabling Routine 3D Cell Culture