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Refeyn launches Two<sup>MP</sup> Auto for automated protein characterisation at single-molecule level in solution

Refeyn

New mass photometer promises rapid, autonomous, and label-free mass characterisation of biomolecules at the single-molecule level

14 Feb 2022
Ellie Abbott
Biochemist

Product news

Refeyn has announced the launch of its new TwoMP Auto mass photometer, a unique instrument for the automatic loading and analysis of biomolecular samples for protein characterisation at the single-molecule level. Launched at SLAS in Boston, the instrument provides researchers with automated direct mass measurements of up to 14 samples in one hour using the unmatched sensitivity and simplicity of mass photometry - Refeyn’s novel molecular mass measurement technology.

The introduction of the TwoMP Auto closely follows the launch of Refeyn’s SamuxMP benchtop mass photometer for AAV analysis, continuing the company’s momentum in product innovations based on mass photometry. The TwoMP Auto represents a significant shift in protein characterisation workflows, enabling scientists to save time and effort through autonomous label-free analysis of biomolecules in solution with minimal sample consumption. Applications of the technology range from purity assessments to interaction analyses. The automation simplifies workflows such as titrations and screening assays, which can be run accurately and reproducibly without operator input, freeing up valuable research time and minimising the chance of human error.

The TwoMP Auto, which integrates a liquid-handling robot, is operated with Refeyn's AcquireMP software. Refeyn’s complete software solution enables the user to define the experimental setup, collect data, and analyse and visualise the results. The robotics unit can also be retrofitted to Refeyn’s existing OneMP and TwoMP mass photometers, and is ideal for any task that requires precise, repeated molecular mass characterisation and comparison of different conditions or sample compositions.

“We are pleased to continue our new product introductions with the launch of our TwoMP Auto mass photometer for the rapid and autonomous direct measurement of molecular mass in a variety of applications”, said Matthias Langhorst, CPO, Refeyn. “We developed the TwoMP Auto to free up valuable time for scientists and enable labs to work more efficiently.”

Mass photometry is a highly novel tool that is unmatched in its versatility and capability in delivering rapid, simple single-molecule measurement. In addition to offering distinct information on individual particles, mass photometry enables more efficient and effective use of existing specialised technologies, for example, in verifying sample quality prior to cryoEM analysis. The technology also provides significant practical benefits over other methods, such as mass spectrometry, size exclusion chromatography, and surface plasmon resonance by removing the need for labels and providing accurate characterisation of biomolecules in solution at the single-molecule level.

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Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Electron MicroscopyElectron microscopes (EM) are used to create high-resolution images of samples at the nanoscale by means of an accelerated beam of electrons as a source of illumination. Types of electron microscope include scanning electron microscopes (SEM), transmission electron microscopes (TEM), scanning transmission electron microscopes (STEM) and cryo-electron microscopes. Focused ion beam (FIB) microscopes are useful for modifying or milling a sample surface with nanometer precision, as well as imaging. Find the best electron microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein InteractionsProtein interactions are essential for understanding cellular processes, as proteins work together to carry out biological functions. Studying protein interactions can provide insights into disease mechanisms, drug development, and cell signaling pathways. Explore the best tools for protein interaction research in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.MicroscopyMicroscopy is a technique used to observe small objects in detail, from cells to materials, using light or electron microscopes. It enables researchers to examine structures with high resolution, aiding in fields such as biology, medicine, and materials science. With advanced microscopy techniques, scientists can gain insights into cellular processes, tissue structures, and material properties. Explore the best microscopy solutions in our peer-reviewed product directory, compare products, read customer reviews, and get pricing directly from manufacturers.CryogenicPhotometryProtein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.

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Refeyn launches Two<sup>MP</sup> Auto for automated protein characterisation at single-molecule level in solution