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Reduce the Cost of High Content Screening

AMSBIO
13 Oct 2010
Sarah Sarah
Marketing / Sales

Product news

The new Oris™ Pro 384 Cell Migration Assay from AMSBIO is the first of a new generation of cell migration assays designed specifically for fully automated high throughput screening (HTS) utilizing high content screening (HCS) and high content imaging (HCI) systems.

The new Oris™ Pro 384 Cell Migration Assay uses a non-toxic biocompatible gel (BCG) to form a centrally located and temporary cell-free zone on cell culture surfaces in a 384-well format. After cell seeding the BCG dissolves to reveal a detection zone into which the migration of cells can be observed either in real time or after further experimental processing. This breakthrough product enables researchers to capture and quantify cell migration data while substantially improving assay efficiency and dramatically reducing assay costs.

Measurement of cell migration enables researchers to better understand the impact of candidate therapeutic compounds on biological pathways and cellular behavior. This new 384-well format assay adds to the 96-well range of Oris™ Pro assays available from AMSBIO and will play an important role in accelerating the development of new therapeutics for wound healing, cancer treatment and other diseases impacted by the movement of cells.

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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Reduce the Cost of High Content Screening