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Real Time Binding Analysis Made Easy with OpenPlex

HORIBA Scientific
2 May 2013

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HORIBA Scientific is pleased to announce the launch of OpenPlex, a flexible research platform for the real time analysis of label-free molecular interactions in a multiplex format.

OpenPlex uses Surface Plasmon Resonance imaging (SPRi) to monitor the binding of molecules to an array of receptors immobilized on a sensor chip. It can give qualitative (Yes/No binding) and quantitative information of the interactions such as concentration, affinity (KD), association and dissociation rates (kon, koff). Molecular interactions involving proteins, DNA, RNA, oligosaccharides, living cells, polymers or nanoparticles can be characterized and quantified.

OpenPlex is the evolution of SPRi-Lab+, the bench-top flexible label-free instrument from HORIBA Scientific. This instrument was designed for simple operation and is adapted to multiple applications covering physico-chemistry, biochemistry, biology and nanotechnology.

Different flow cell configurations are available, making the combination of label-free molecular interaction analysis to fluorescence or electrochemistry even easier. This new design will facilitate cutting-edge research, from nanotechnologies to biomedical research.

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OpenPlex - Flexible Surface Plasmon Resonance Imaging System

HORIBA Scientific

Designed to meet the demands of biologists, biochemists and biophysicists, the OpenPlex is a flexible surface plasmon resonance imaging system. OpenPlex is your companion for the development of label-free and multiplexed bio-assays and molecule detection. It is a robust and compact system designed for simple use and high versatility. Its open format, dedicated sensor chips and manual operation enable numerous types of experiments to be explored without compromise, covering chemistry, biochemistry, physico-chemistry and biomolecular interactions. Open your research areas with OpenPlex! Choose between three different flow cell configurations without concession: • Normal flow cell for standard surface plasmon resonance imaging experiments • Window flow cell, compatible with fluorescence measurements • Cuvette cell, compatible with electrochemistry measurements

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BiosensorsBiosensors are devices used to detect an analyte using biological molecules specific to the analyte coupled to a detector. Biosensor instruments may be photometric, typically using surface plasma resonance (SPR), electrochemical or QCM (quartz crystal microbalance) biosensors. Biosensors should be selective, portable, robust and sensitive and have a fast response time. Systems may be manual or automated and usually have associated software.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.NanotechnologyNanotechnology, or nanotech, is an engineering technique using molecular scale functional systems. Applications of nanotechnology include medicine and medical devices, electronics, air and water purification, food science and energy production.Sensor ChipSurface Plasmon ResonanceLabel-Free AnalysisNanoparticlesNanoparticles are between 1-100nm in size. Nanoparticles can be used for a wide variety of applications including biomedical, catalysis and electronics.

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