Rapid, Efficient Identification and Measurement of Biomarkers

12 Feb 2007

Product news

ESA Biosciences Inc. has announced that its Metabolomics System is providing researchers with a powerful tool to identify and monitor small molecule cellular biomarkers of disease and disease treatment.

Based upon the company's proprietary CoulArray® technology, the system uses a series of highly efficient coulometric electrochemical cells to specifically monitor metabolically active small molecule cellular components. Combining the well-known sensitivity and selectivity of electrochemical detection with a powerful data-analysis package, the Metabolomics System enables rapid and sensitive identification and measurement of physiologically relevant biomolecules even in highly complex samples.

To fully understand and appreciate a biological system requires an understanding of the small organic molecules (anti-oxidants, enzyme co-factors, cellular metabolites, vitamins, etc.) responsible for the maintenance of routine physiological functions. Changes in the levels of these molecules caused by disease or external stimuli can play an important role in the development or progression of disease and in understanding and measuring adverse drug effects. The Metabolomics System offers the advantage of being able to study a variety of molecules quickly and accurately. In addition, the system can distinguish minute changes in metabolomics patterns and components.

ESA Biosciences, Inc. enables answers to pressing applications challenges by applying its expertise in specialty detection and electrochemistry, combined with components, kits, and reagents, for analytical laboratories, commercial diagnostics laboratories, and the clinical point-of-care setting. ESA is a wholly owned subsidiary of Magellan Biosciences, Inc. For more information, visit the article webpage.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Clinical TrialsClinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. Clinical Trials are a phased process (Phase 0, Phase I, Phase II, Phase III and Phase IV) which begins after initial preclinical testing.
Rapid, Efficient Identification and Measurement of Biomarkers