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Psomagen fills need for genomic surveillance of SARS-CoV-2 variants

Psomagen, Inc.
21 Jun 2021
Diane Li
Assistant Editor

Industry news

Psomagen, Inc., a US-based genetic sequencing and data analysis service provider, is collaborating with Swift Biosciences (now part of Integrated DNA Technologies), a pioneer in the development of research-use-only library preparation kits, to offer comprehensive SARS-CoV-2 variant determination using next-generation sequencing (NGS).

Early in the pandemic, public health officials recognized the need to characterize the virus that causes COVID-19. But as the virus spreads, managing the volume of patient samples slated for sequencing for surveillance research has become a challenge.

That’s where Psomagen’s partnership with Swift comes in.

Psomagen currently offers two EUA-approved COVID-19 diagnostics tests including SalivaDirect and the Psoma COVID-19 RT Coronavirus Test. Adding the Swift Normalase®️ Amplicon SARS-CoV-2 Panel (SNAP) has allowed them to diversify existing screening efforts to include variant profiling.

“Our labs have scaled up and we are ready to help our peers trying to balance COVID-related sequencing with non-COVID projects,” said Ryan Kim, Chief Executive Officer at Psomagen. “Getting these samples processed quickly is important because the resulting information is helping to fight against the spread of the disease.”

Swift’s SNAP SARS-CoV-2 overlapping primers may help facilitate 99.7% coverage of the SARS-CoV-2 genome. The one-tube multiplex technology facilitates identification even in cases where a mutation occurs under a primer binding site.

“That means the data is really accurate—if there are variants from the original NCBI Reference Sequence NC_045512.2 Wuhan-Hu-1, you will see it,” said Jordan RoseFigura, Director of Manufacturing Sciences at Swift Biosciences. “That is crucial because even the slightest genetic anomaly could change the severity and transmissibility of the disease.”

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Library PreparationLibrary preparation is a critical step in sequencing workflows, where DNA or RNA samples are converted into libraries for high-throughput, next generation sequencing. This step ensures accurate results and minimizes biases. Explore library preparation kits in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Clinical NGSNext Generation Sequencing (NGS) refers to the use of massive parallel sequencing of multiple small fragments of DNA. This high-throughput genomic analysis yields enormous amounts of sequence data, which if appropriately analyzed could have huge potential for clinical laboratories. For this to happen there are technique and bioinformatic hurdles to be overcome.SequencingSequencing refers to determining the order of nucleotides in a DNA or RNA molecule. This process is essential in genomics, diagnostics, and evolutionary biology. Techniques like next-generation sequencing (NGS) and Sanger sequencing provide high-throughput and precise data for analyzing genomes and transcriptomes. Browse our peer-reviewed product directory to find the best sequencing tools and reagents, compare products, check reviews, and get pricing directly from manufacturers.Genome SequencingGenome sequencing involves determining the complete DNA sequence of an organism's genome. It provides crucial information about genetic variations, mutations, and diseases. Advances in sequencing technologies, such as next-generation sequencing (NGS), have accelerated research in genomics, diagnostics, and personalized medicine. Explore genome sequencing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.CoronavirusCoronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases like COVID-19. Research into the biology, transmission, and treatment of coronaviruses has become a global priority, particularly since the emergence of SARS-CoV-2. Understanding the virus�s structure and behavior is essential for developing vaccines, diagnostics, and antiviral treatments. Explore our peer-reviewed product directory to discover the latest research tools, diagnostic tests, vaccines, and treatments for coronavirus, compare products, read reviews, and receive pricing directly from manufacturers.Covid-19COVID-19, caused by the SARS-CoV-2 virus, has led to a global health crisis with profound impacts on societies and economies. Research into diagnostics, vaccines, treatments, and understanding viral mechanisms continues to evolve. The pandemic has accelerated innovations in healthcare and biopharmaceuticals, including novel vaccine platforms and rapid testing technologies. Browse our peer-reviewed product directory to find top COVID-19 testing kits, research tools, vaccines, and treatments, compare products, read reviews, and receive direct pricing from manufacturers.Infectious DiseasesInfectious diseases are caused by pathogens such as bacteria, viruses, and fungi. Effective detection, prevention, and treatment are crucial to control outbreaks and improve public health. Diagnostic tools, vaccines, and antimicrobial treatments are essential components of managing these diseases. Research into emerging pathogens and resistance patterns continues to evolve. Browse our peer-reviewed product directory to find the best diagnostic tools, prevention solutions, and treatment options; compare products, read customer reviews, and get pricing directly from manufacturers.

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Psomagen fills need for genomic surveillance of SARS-CoV-2 variants