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Proven Liquid Handling for Reliable Molecular Biology Processes

Analytik Jena GmbH+Co. KG
26 Sept 2007

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Solutions that combine reliable nucleic acid purification processes with precise low volume pipetting capacity are rarely available.

As the first company with a 384-tip simultaneous pipetting head, CyBio established a benchmark for automated high throughput screening devices in 384- and 1536-well formats. Today, CyBio still maintains the gold standard for automated pipettors.

Now CyBio transfers its high-grade expertise in handling small volumes by introducing the CyBi®-GeneRobots, a product family of functionally designed systems to automate applications in molecular biology. Carefully designed instrument details allow effective automation of time consuming and strenuous laboratory procedures.

At Biotechnica 2007 in Hannover, Germany CyBio presents 3 products of the CyBi®-GeneRobots line at their booth number 16 in hall 8.

The CyBi®-DiluSpro is an 8 channel pipettor perfectly suited for many molecular biology applications. Through the high precision over the entire pipetting range of 0.5 µL -250 µL, the CyBi®-DiluSpro is the optimal choice for PCR set & clean up, as well as sequencing reaction set & clean up. The functional design enables easy integration to laminar flowboxes and the opportunity to change tips during the process avoids cross-contamination. The flexible carriage design accommodates a wide range of reagents and samples. With the help of the user-friendly CyBio® Composer software, application specific protocols can be quickly programmed and run.

The CyBi®-Well vario is a multi-channel pipettor, perfectly suited for nucleic acid transfer applications in the 96-, 384-, and 1536 well format, such as high throughput siRNA screenings. Exchangeable pipetting heads covering a volume from 25 nL up to 250 µL provide flexibility from the downscaling of reaction volumes to throughput increases. Sterile and PCR-certified disposable tips promise highly reliable results without any cross-contamination. CyBio’s core pipetting technologies enable gentle cell handling as well as rapid nucleic acid transfer protocols on the same instrument.

The CyBi®-RoboSpense is an all-purpose pipetting robot with 4 or 8 individually addressable channels, ideal for nucleic acid purification, processing and analysis applications. The system works with tubes and plates both in the 96 and 384-well format, delivering precise, highly reproducible results, right from the start. The CyBi®-RoboSpense is designed for fully automated sample purification and reaction set & clean up tasks. It is ideal for all labs that are looking for a versatile system that automates a wide variety of molecular biology applications.

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Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.RNA InterferenceRNA interference (RNAi) uses siRNA or miRNA for transcriptional silencing, gene knockdown and regulation of gene expression. RNAi requires chemical synthesis, introduction of DNA vectors into cells, an assay of RNAi effects and RNAi quantification or analysis. Consider target sequence selection, reagent preparation, controls, high specificity and effectiveness and low non-specific gene knockdown.

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