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Proteomics on NGS: The launch of Olink Explore 1536 promises to be a game changer

Olink Proteomics

Olink Proteomics have announced the launch of Olink® Explore 1536

7 Jun 2020
Sophie Ball
Publishing / Media

Product news

Olink Proteomics has announced the launch of Olink® Explore 1536, combining the company's unique proximity extension assay (PEA) high-multiplex immunoassay technology with next-generation sequencing (NGS) readout on the Illumina® NovaSeq platform.

Olink Explore 1536 has several groundbreaking features that promise to overcome significant limitations in other proteomic technologies, including remarkably increased performance in terms of multiplexing and throughput. They have achieved these dramatic improvements while maintaining the same robust, transparent and thorough validation of each assay as previously, generating reproducible and precise data that can be trusted.

"I am extremely proud of the Olink team that has been able to take this technology leap and apply NGS as our readout platform. A lot of efforts have been made to respond to a rapidly growing unmet need; drastically increase multiplexing, throughput, drive cost down and leveraging a large installed base to increase access. It is also important that we will rapidly expand our strictly validated protein biomarker library, now in excess of 1500, next year beyond 3000 and reaching 4500 in 2022. This new platform marks a pivotal moment in the field, taking discovery in proteomics to unparalleled levels and supporting our vision to enable the understanding of real-time human biology in a liquid biopsy", says Jon Heimer, CEO, Olink Proteomics.

"I think that Olink will be an important addition to the tools we have for biomarker discovery in plasma, CSF, and other biofluids due to the speed and very small sample amounts required for analysis", says Professor Steven Carr, Senior Director of Proteomics at the Broad Institute.

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BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.SequencingSequencing refers to determining the order of nucleotides in a DNA or RNA molecule. This process is essential in genomics, diagnostics, and evolutionary biology. Techniques like next-generation sequencing (NGS) and Sanger sequencing provide high-throughput and precise data for analyzing genomes and transcriptomes. Browse our peer-reviewed product directory to find the best sequencing tools and reagents, compare products, check reviews, and get pricing directly from manufacturers.Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.

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Proteomics on NGS: The launch of Olink Explore 1536 promises to be a game changer