Proteintech Accelerates siRNA Knockdown Validation Initiative

Original antibody manufacturer continues to raise industry standards through siRNA and Antibody Exchange Program

16 Dec 2015
Weylan Kiam-Laine
Microbiologist

Industry news

Proteintech Group, the benchmark in antibodies, have announced the rapid expansion of its siRNA validation program to have their entire portfolio verified by this advanced technique over the next several years. The original antibody manufacturer, which makes each one of their more than 12,000 products in-house from start to finish, became the first company to implement the knockdown method starting in 2014. The higher standard of testing is being done to protect researchers in an antibody market laden with problems stemming from reliability and will not result in price increases.

While there are many high-quality antibodies on the market, they are often hidden amongst ones that disrupt and delay science. Weeding out the rubbish wastes valuable time and grant money. As the company continues to lead the antibody revolution, Proteintech is also announcing an extension to its Antibody Exchange Program, which allows a scientist to swap any competitor’s failed antibody for the equivalent from the Proteintech catalogue at no charge. The initiative will now continue in the U.S. until June 30, 2016.

"Antibodies are such a vital part of research, and antibody companies must meet their obligations to be transparent and offer the best quality products," said Jason Li, Ph.D., chief executive officer of Proteintech. “We are taking these next steps with confidence that our antibodies will work correctly and challenge the rest of industry to meet us in the efforts to improve scientific reproducibility.”

Proteintech will add the technical specifications and validation details, including siRNA results, as the program progresses.

The Antibody Exchange Program is open to both new and existing customers, even those who have previously participated in the exchange.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.RNA InterferenceRNA interference (RNAi) uses siRNA or miRNA for transcriptional silencing, gene knockdown and regulation of gene expression. RNAi requires chemical synthesis, introduction of DNA vectors into cells, an assay of RNAi effects and RNAi quantification or analysis. Consider target sequence selection, reagent preparation, controls, high specificity and effectiveness and low non-specific gene knockdown.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.Protein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.siRNASecondary AntibodiesMethod ValidationMethod validation is the process used to prove that the analytical procedure used for a particular test is capable of providing suitable data.Antibody ProductionAntibody production is essential for a wide range of applications in biochemistry and immunology. Ensuring high-quality monoclonal and polyclonal antibodies are produced is key. Explore antibody production tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.
Proteintech Accelerates siRNA Knockdown Validation Initiative