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Predictive Biosciences to Present at Next-Generation Sequencing Conferences

20 Aug 2012
Sonia Nicholas
Managing Editor and Clinical Lead

Industry news

Predictive Biosciences, an innovative developer of molecular diagnostic tests, has announced that the company will present at the NGx: Applying Next-Generation Sequencing Conference in Providence, RI on Tuesday, August 14, 2012 at 11:45 a.m. (EST).

In a presentation entitled, “A Cost Effective Assay for Multiplexing Protein and DNA Biomarkers on a Single Analytical Platform,” Anthony P. Shuber, chief technology officer, will discuss the company’s use of next generation sequencing to simultaneously detect protein and DNA biomarkers on one analytical platform. The method developed can eliminate the need to perform separate procedures for protein and DNA while decreasing assay complexity and cost. Mr. Shuber will also chair a technical session at the meeting on tips and tricks for the application of next generation sequencing on Tuesday, August 14 at 9:30 a.m. (EST).

The Company recently launched a sequencing-based version of its CertNDx Bladder Cancer Assay which uses a NGS sequencing platform to detect FGFR3 mutations that are indicative of bladder cancer. “We are very excited about the progress we have made applying next generation sequencing to clinical diagnostics.” said Marc Schneebaum, chief executive officer, “We believe this approach can be applied to other cancer markers and bodily fluids to greatly improve clinical performance and ultimately, patient management. We are pleased to have Tony serve as a speaker and panel chair, given the Company’s record of innovation and technology leadership.”

Mr. Shuber will also be presenting “Incorporating Next-Gen Sequencing into the Clinical Environment” at the upcoming Next Generation Dx Summit in Washington, DC on Tuesday, August 21 at 3:20 p.m. (EST). The presentation will focus on the recently developed assay that uses NGS to detect single mutant molecules of FGFR3 in urine. The assay performance resulted in mutation detection in urine that is >90% concordant with that found in tissue.

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Gas ChromatographyGas chromatography (GC) is an analytical technique used to separate and quantitate mixtures of small and volatile compounds. Gas chromatographs or GC systems include components such as GC columns, detectors, pumps and autosamplers. Choose from packed or capillary GC columns, flame ionization (FID), photoionization (PID) electron capture detectors and selective or non-selective detectors. Find the best gas chromatographs in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cancer DiagnosticsThere are a wide variety of diagnostic tests for cancer available, and this range continues to expand as our knowledge of cancer improves. Current diagnostic methods include biopsy, imaging and blood tests for known biomarkers. New methods in research development include liquid biopsies and cancer breathalyzers.Clinical NGSNext Generation Sequencing (NGS) refers to the use of massive parallel sequencing of multiple small fragments of DNA. This high-throughput genomic analysis yields enormous amounts of sequence data, which if appropriately analyzed could have huge potential for clinical laboratories. For this to happen there are technique and bioinformatic hurdles to be overcome.

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Predictive Biosciences to Present at Next-Generation Sequencing Conferences