Potent Reagent for Reliable Stem Cell Differentiation

AMSBIO announces ec23® - a stable synthetic retinoid that has been proven in independent testing to potently induce and reliably control stem cell differentiation.

Stem cells self renew and have the ability to differentiate into a variety of cell types. They represent a valuable renewable resource from which functional tissues can be derived. Such materials can subsequently be used for research, disease modeling, drug testing and ultimately therapeutic applications.

Controlling cell differentiation in a predictable way is a major challenge in stem cell research. Although natural retinoids such as All-Trans Retinoic Acid (ATRA) can be used to trigger neuronal stem cell differentiation, they are inherently unstable, leading to partially differentiated cultures and variable results. ec23®, which remains chemically and physically stable under normal laboratory conditions, overcomes these challenges and offers additional useful features for stem cell differentiation.

ec23® enables the robust and reproducible differentiation of stem cells and progenitor cells. With higher stability in tissue culture medium and more potency as a differentiation factor than retinoic acid, ec23® produces down regulation of markers associated with the pluripotent stem cell phenotype and increased expression of differentiation markers. The differentiation of neural tissues is clearly observed and additionally ec23® has been noted to trigger digit duplication during targeted release in the chick embryo, underlining its potency as a regulator of tissue development.

As a potent inducer of neurogenesis - ec23® maximizes the consistency and efficiency of neural stem cell differentiation and opens up a wealth of applications in basic research screening, toxicological testing and disease modeling.

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