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Postnova Launch EAF2000 for Characterization of Complex Charged Molecules

Postnova Analytics GmbH

New electrical and asymmetrical flow field flow fractionation system improves separation of molecules

22 Oct 2017
Abigail Berry
Administrator / Office Personnel

Product news

Postnova Analytics announces the launch of the EAF2000 - an innovative new simultaneous Electrical and Asymmetrical Flow Field Flow Fractionation (EAF4) system designed to enhance separation and characterization of biopharmaceutical, environmental and nanomaterials.

EAF4 technology uniquely combines the principle of Electrical and Asymmetrical Flow FFF in just one system. In an EAF2000 system - Electrical and Cross Flow Fields are applied simultaneously across the FFF channel enabling separations by particle size and particle charge based on electrophoretic mobility. Combining these two powerful separation techniques in a single platform opens the door to characterizing complex proteins, antibodies and viruses as well as environmental and charged nanoparticles or polymers that have proven intractable to other techniques.

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The EAF2000 system integrates Postnova's market-leading AF2000 Asymmetrical Flow FFF system, with an additional Electrical FFF module, special EAF4 channel and easy-to-use software platform. The new PN2410 Electrical FFF module is used to establish and precisely control the Electric Field allowing constant and reproducible separation conditions. This module and the EAF4 channel are connected to a standard AF2000 Flow FFF system which is controlled by the NovaFFF - EAF4 software which provides constant current operation and data evaluation for electrophoretic mobility calculation.

Modular in design, the AF2000 FFF system incorporates the combined experience, expertise and technological advances from Postnova Analytics' nearly two decades of leadership in FFF. Incorporating a range of FFF modules in a single integrated system to provide universal separation, the AF2000 offers more flexibility, better performance and more robust results than any system before. The AF2000 FFF system is available with a wide range of add-on modules, extra options and special FFF detectors, such as Refractive Index (RI), Multi-Angle Light Scattering (MALS) and Dynamic Light Scattering (DLS). All Postnova FFF modules and detectors have been especially developed for FFF and are perfectly optimized not only for the use with the AF2000 but also for easy interfacing with high-end detection technologies from other suppliers that may already be at use in your laboratory.

Request more information about the EAF2000 system here

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Ion ChromatographyIon chromatography, also known as ion exchange chromatography, is a high-performance liquid chromatographic technique used for the separation and identification of ions or polar molecules in a sample, including proteins, nucleotides and amino acids. Equipment includes ion exchange columns, ion exclusion columns, ion chromatography systems, pumps, and detectors. Find the best ion chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Size Exclusion ChromatographySize exclusion chromatography (SEC) is a liquid chromatographic technique used to separate and identify molecules based on their size, including polymers, proteins, nanoparticles & nucleic acid. SEC is further subdivided into gel filtration chromatography (GFC) and gel permeation chromatography (GPC) when an aqueous or organic mobile phase is used respectively. HPLC-based SEC systems and columns are available for analytical separation alongside SEC spin columns or filters to prep samples for many protocols. Find the best size exclusion chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Environmental AnalysisEnvironmental analysis describes a variety of tests that determine the effect of chemicals, processes and particulates such as persistent organic pollutants (POPs) have on the environment.NanomaterialsNanomaterials such as carbon nanotubes, fullerenes and nanoparticles are a group of materials that measure between 1-1000nm for a single unit. Analysis techniques include AFM, electron microscopy and super resolution microscopy.Ion Separation

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Postnova Launch EAF2000 for Characterization of Complex Charged Molecules