Positively Charged Nylon Membrane Filter from Porvair Produces Highly Effective Reduction of Endotoxins

Porvair Filtration Group has introduced Hydrofil HTZ – an innovative dual 0.2µm membrane sterilization filter cartridge that incorporates a pharmaceutical grade, positively charged Nylon 6,6 membrane. The positive zeta-potential of the nylon membrane enables highly effective reduction of most endotoxins derived from bacteria which typically have a negative charge in water. The dual membrane structure results in a significant increase in the endotoxin adsorption capacity of the filter.

Applications for Hydrofil HTZ include GMP pharmaceutical grade water systems where endotoxins levels need to be kept below Limulus Amebocyte Lysate (LAL) assay detection limits and recirculation of parenteral products through endotoxin removal filters to allow batch release.

Hydrofil HTZ filters are highly resistant to integrity failure caused by steam sterilization or autoclave cycles and have excellent chemical compatibility characteristics. Porvair’s sterilizing grade cartridges are integrity tested, with each individual module’s value recorded to ensure product safety. The materials of construction are approved by the Federal Drug Administration (FDA) and meet the standards of the United States Pharmacopeia Class VI (USP VI).