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Portrait™ 630 Reagent Multi-spotter Wins R&D100 Award

22 Aug 2007

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Labcyte Inc. announced today that the Portrait 630 reagent multi-spotter has been selected by an independent panel and the editors of R&D Magazine as one of the 100 most technologically significant products introduced into the marketplace over the past year.

The Portrait 630 reagent multi-spotter uses the Labcyte acoustic droplet ejection technology to bring automated reagent deposition to the new field of MALDI tissue imaging mass spectrometry (IMS). IMS links the label-free universal detection of mass spectrometry with the spatial information of molecular histology. IMS enables discovery in protein profiling, small molecule tracking, and other applications. The Portrait 630 reagent multi-spotter provides multi-step protocols, precise drop-on-drop positioning and flexible droplet timing, to automate sequential experiments such as proteolytic digests followed by matrix deposition. The Portrait 630 system enables users to optimize reaction conditions and crystal formation for more reproducible and higher quality mass spectra.

“We are very pleased that the Portrait 630 was chosen for this award,” said Elaine J. Heron, PhD, Chief Executive Officer of Labcyte Inc., “Our development team brings tremendous expertise from diverse fields to create innovative products. This instrument will enable important discovery and growth in new markets such as imaging mass spectrometry.”

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein CrystallographyProtein crystallization is the process of crystallizing purified proteins for 3D structure analysis by x-ray crystallography. The main methods of protein crystallization include sitting drop, hanging drop and microbatch. It is important to control parameters such as pH, temperature and concentration. Following crystallization, detectors and software are used for data collection and analysis.

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Portrait™ 630 Reagent Multi-spotter Wins R&D100 Award