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Polyplus builds on research and commercial mRNA support portfolio with new transfection reagent

Polyplus Transfection

New transfection reagent is an efficient, stable, and safe delivery system leading to 100% mRNA encapsulation for comparable LNP delivery

13 Sept 2022
Blake Forman
Content Creator

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Polyplus, a leading upstream solutions provider for advanced biologic and cell and gene therapy production from research to commercial grade, continues to build out the mRNA support portfolio. The team has launched in vivo -jetRNA®+ transfection reagent for in vivo mRNA delivery using a preformed liposome.

The new in vivo- jetRNA®+ transfection reagent is an efficient, stable, and safe delivery system leading to 100% mRNA encapsulation for comparable LNP delivery. The ready-to-use format eliminates formulation steps, and the stable liposome size allows for low to high mRNA concentration over time. Applications include prophylactic vaccines, mRNA therapeutics (cancer therapy, rare disease, etc.), and gene editing. A unique feature is the ability to target multiple organs via systemic injection routes in various models with no limitation to liver only.

“Polyplus is known for in vivo delivery expertise, and we have continued to grow this foundational portfolio guided by the voice of the market. In 2007, we launched GMP grade in vivo-jetPEI® reagent,” said Mario Philips, CEO at Polyplus. “In vivo-jetRNA® transfection reagents were then launched in 2019 in ready-to-use and customizable injectable formats for vaccine developers, anti-cancer research, and in vivo functional studies. Now in vivo-jetRNA®+ transfection reagents are being launched to further support the growing demand of mRNA developers.”

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Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.RNA InterferenceRNA interference (RNAi) uses siRNA or miRNA for transcriptional silencing, gene knockdown and regulation of gene expression. RNAi requires chemical synthesis, introduction of DNA vectors into cells, an assay of RNAi effects and RNAi quantification or analysis. Consider target sequence selection, reagent preparation, controls, high specificity and effectiveness and low non-specific gene knockdown.TransfectionTransfection introduces nucleic acids (DNA or RNA) into cells, facilitating gene expression, genome editing, and functional studies. It�s widely used in genetic research, drug discovery, and therapeutic development. Find transfection reagents, kits, and systems in our product directory with reviews and pricing options.RNARNA is a nucleic acid that plays a key role in gene expression and protein synthesis. It serves as a messenger between DNA and ribosomes, carrying genetic instructions to produce proteins. Advances in RNA-based therapies, such as mRNA vaccines and gene editing, have revolutionized treatment strategies for genetic disorders and infectious diseases. Explore RNA research tools and therapies in our peer-reviewed product directory; compare products, check customer reviews, and get pricing directly from manufacturers.Gene EditingGene editing is the precise alteration to an organism's DNA, with CRISPR being the most well-known technique. It is used in a wide range of applications, including the development of disease models and gene therapy, and crop improvement. Browse our peer-reviewed product directory to find the best gene editing solutions, compare products, check reviews, and get pricing directly from manufacturers.

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