Plexpress to Showcase ADME-Tox Offering at Eurotox 2012

11 Jun 2012

Product news

Plexpress, creator of the innovative TRAC high sample-throughput platform for gene expression analysis, is to showcase its ADME-Tox offering at this year’s Eurotox meeting in Stockholm (17-21 June). TRAC is ideal for ADME-Tox studies as it allows the rapid, accurate and cost-effective analysis of thousands of samples, with multiplex of up to 30 genes per sample, providing expression profiles for all key genes in a single, fast experiment.

Dr Jari Rautio, Plexpress’ CEO, will be at stand 32 along with the rest of the Plexpress team to discuss the benefits of ADME-Tox screening using the TRAC approach, as well as to outline some successful recent projects completed by the company. These include the analysis of human cytochrome P450 expression in primary hepatocytes and the screening of ADME-Tox markers from rat liver samples. They will also be providing details of Plexpress’ integrated gene expression service, which offers a ‘one-stop-shop’ for studies requiring genome-wide mRNA and miRNA biomarker discovery all the way through to focused, target-specific analyses using many samples.

As part of its offering, Plexpress also provides pre-validated TRAC ADME-Tox panels designed to yield excellent performance when working with human and rat models during pre-clinical drug testing. The company can also develop custom panels of up to 30 genes for any species with known sequence data, based on customer requests. For more information please visit the Plexpress website.

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ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Eurotox
Plexpress to Showcase ADME-Tox Offering at Eurotox 2012