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Phase Genomics collaborates with Element Biosciences to optimize cytogenomics for liquid and solid tumor samples

Phase Genomics

The Element AVITI™ System rapidly delivers high-quality, cost-effective data to accelerate cytogenomic research on Phase Genomics’ OncoTerra™ Platform

18 Apr 2023
Georgina Wynne Hughes
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Phase Genomics, Inc., a leading developer of cutting-edge genomic solutions, and Element Biosciences, the developer of an innovative DNA sequencing platform disrupting genomics, released new details of their first collaboration leveraging Phase Genomics’ proprietary OncoTerra™ cytogenomics platform and the Element AVITI System for next generation sequencing (NGS). Data generated from AVITI showed improvements in several key sequencing metrics, making it an ideal technology to pair with the proximity ligation-based OncoTerra™ cytogenomics platform for cancer research.

“We’re extending the application of our core technologies into the oncology space, ensuring Phase Genomics’ next-generation cytogenomic tools deliver unparalleled precision, speed, and efficiency. We’re excited by what we’re seeing as a result of this recent work with Element,” said Ivan Liachko, PhD, co-founder and CEO of Phase Genomics. “Although OncoTerra is NGS platform agnostic, the high quality and accuracy of Element’s AVITI System make it a great option for data generation in next generation cytogenomics.”

The OncoTerra Platform paired with the AVITI System enables high-resolution cytogenomic analysis of solid-tumor samples, including archival formats, such as formalin-fixed, paraffin-embedded (FFPE) samples, that are largely unsuitable for conventional cytogenetic assays. Data generated on the Element AVITI System shows a lower level of duplicates and a higher proportion of high-quality read pairs. This increases the efficiency of OncoTerra library sequencing. OncoTerra delivers genome-wide cytogenomic insights from a wide array of sample types, including blood, fresh, and frozen tissues. Phase Genomics’ OncoTerra platform is the first offering to deliver the value of scalable cytogenomics for solid-tumor malignancies in the research setting.

“Our work with Phase Genomics marks Element Biosciences’ first foray into the next-generation cytogenomics space for oncology,” said Shawn Levy, PhD, CSO and SVP of Applications at Element Biosciences. “Our collaborative work with Phase Genomics underscores the versatility of the AVITI System in accurate genomic characterization of clinically relevant samples. Phase Genomics’ innovative approach to cytogenomics amplifies our joint impact in oncology research today, advancing the latest technology toward the clinic.”

The OncoTerra platform leverages data from ubiquitous short-read sequencing technologies, like the Element AVITI NGS system, to identify novel and known genomic alterations. This information is key for oncology research applications. Phase Genomics and Element will share additional details and an application note at the AACR conference, April 14-19 (Phase Genomics booth #561, Element Biosciences booth #559). The application note demonstrates that with a single NGS-based assay, OncoTerra surpasses the breadth and depth of insights from current front-line cytogenetic diagnostics, including karyotyping, fluorescence in situ hybridization (FISH), and chromosomal microarrays.

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DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.SequencingSequencing refers to determining the order of nucleotides in a DNA or RNA molecule. This process is essential in genomics, diagnostics, and evolutionary biology. Techniques like next-generation sequencing (NGS) and Sanger sequencing provide high-throughput and precise data for analyzing genomes and transcriptomes. Browse our peer-reviewed product directory to find the best sequencing tools and reagents, compare products, check reviews, and get pricing directly from manufacturers.CytogeneticsTumorsTumor research focuses on understanding abnormal cell growth that leads to cancer. Identifying biomarkers, studying tumor microenvironments, and developing targeted therapies are critical for advancing cancer treatment. Early detection and personalized treatment options are key to improving outcomes for patients. Browse our peer-reviewed product directory to explore tools for tumor research, diagnostics, and cancer therapies; compare products, read customer reviews, and get pricing directly from manufacturers.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.

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