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PharmaFluidics announces ultra-sensitive second generation µPAC™ technology for unbiased single-cell proteomics

PharmaFluidics
18 Feb 2021
Meg Hicks
Student / Graduate

Industry news

PharmaFluidics has announced that researchers of Karl Mechtler’s Group at the Research Institute for Molecular Pathology in Vienna have integrated its ultra-sensitive second generation µPAC™ micro-Chip technology as a key enabler in their advanced Single Cell Proteomics workflow.

A newly published joint study available on bioRxiv discloses a 10-fold increase in detection sensitivity, achieved using PharmaFluidics’ second generation µPAC™ technology in an optimized workflow, as compared to previous reports.

Key results include untargeted and unbiased analysis achieving identification depth of over 2,000 protein groups from as little as 500 picogram of HeLa tryptic digest.

“The microstructured and extremely reproducible µPAC™ microfluidic devices are conducive to the generation of high-quality data. With the further downscaling of the critical dimensions in our second-generation technology from 2,5 µm to 1,25 µm, we are now definitely opening a new league in proteomics LC, as indicated by the order of magnitude improvement in sensitivity for limited sample workflows” Paul Jacobs, co-founder and COO at PharmaFluidics commented.

“We are grateful to IMP researchers for bringing PharmaFluidics’ technology to the forefront of protein biology, and to our own staff for relentless support to their fellow-scientists”, added Johan Devenyns, CEO.

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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Protein ExpressionProtein expression is the utilization of cell machinery for the synthesis of proteins and has become a critical tool in biotherapeutic, genomic, and proteomic research. Produce recombinant proteins with expression vectors in combination with a host cell suitable for high-level protein expression. For production of toxic proteins, consider cell-free expression vectors. Create and monitor post-translational modifications with protein modification kits. Find the best protein expression products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Digital PathologyDigital pathology involves the use of digital imaging and computational tools to analyze pathology slides. It is transforming diagnostics, research, and education by offering enhanced image storage and analysis. Explore digital pathology solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Protein DetectionProtein detection techniques are essential for understanding protein expression, localization, and function. Methods such as western blotting, ELISA, and mass spectrometry are commonly used in research and diagnostics. Browse our peer-reviewed product directory to find the best tools for protein detection, compare products, check reviews, and get pricing directly from manufacturers.Single Cell Genomics

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PharmaFluidics announces ultra-sensitive second generation µPAC™ technology for unbiased single-cell proteomics