NewsLab Automation
PerkinElmer to Showcase Portfolio of Automation and Screening Technologies at SLAS 2017
6 Feb 2017
Lois Manton-O'Byrne, PhD
Executive Editor
Industry news
PerkinElmer, Inc., a global leader committed to innovating for a healthier world, today announced that it will display several automation, high-throughput and phenotypic screening technologies at the 2017 Society for Laboratory Automation and Screening (SLAS) Conference, Walter E. Washington Convention Center, Washington, D.C. at booth 623 and 637 (adjacent). This event brings together researchers to work toward the goal of advancing life sciences R&D by using technology.
“In today’s competitive and continually evolving research setting, we understand that breakthroughs can’t wait,” said Jim Corbett, Executive Vice President and President, Discovery & Analytical Solutions, PerkinElmer. “Our technologies provide automation and improve efficiencies in the lab, helping scientists make new discoveries.”
PerkinElmer will highlight several innovative technologies:
- Kits and Reagents for High-Throughput Screening:provide a wide range of options in multiple assay formats that include Alpha, LANCE® TR-FRET, lites luminescence, and AlphaLISA® SureFire® Ultra™. PerkinElmer will introduce its two newest luminescence assays at SLAS: twinlite™ – a dispense and read, dual luciferase (firefly & renilla luciferase) luminescence assay system and sensilite™ – a highly sensitive, dispense & read firefly luciferase luminescence assay.
- Operetta® CLS™ High-Content Analysis System: enables scientists to uncover deep biological understanding from everyday assays and innovative applications. The system features a unique combination of technologies to deliver the speed, sensitivity and resolution needed to reveal fine sub-cellular details. When paired with PerkinElmer’s Harmony 4.5 software, the Operetta CLS platform can help users find the most subtle phenotypic changes.
- JANUS® G3 Automation Liquid Handling Workstations: deliver real-time and future adaptability in throughput, capacity, and dynamic volume range from 0.5 μl to 5000 μl for consistent and reproducible sample preparation. The workstations feature a choice of pipetting heads, gripper options, and application accessories for complete, walk-away automation.
- EnSight™ Multimode Plate Reader: combines labeled, label-free, and fast imaging technologies on one powerful platform, making it ideal for cell-based assays. With the EnSight imaging module, scientists can image a 384-well plate in less than five minutes. The new Kaleido™ 2.0 data acquisition and analysis software enables easy set-up and running of imaging applications using ready-made, click-and-go protocols or building one’s own from the toolbox. A plate stacker can be added for the convenience of walkaway operation.
- LabChip®GX Touch System: offers researchers microfluidics technology that performs reproducible, high-resolution, electrophoretic separations. A variety of assay kits are available to automate DNA and RNA sizing and quantitation of both fragments and smears to address multiple input concentration ranges.
- chemagic™ 360 Instrument: a medium-to-high-throughput nucleic acid extractor based on proprietary chemagen magnetic bead technology that can analyze up to 50 μg DNA/mL blood and up to96 samples/hour – for sample volumes from 10 μL-10 mL. This instrument delivers pure, ready-to-use, high yield DNA/RNA for a variety of sample types including blood, plasma and saliva. Researchers leverage PerkinElmer’s chemagen offerings in automated nucleic acid isolation to simplify their workflows for a wide range of NGS and PCR applications in the field of human genetics/biobanking, HLA typing, pathogen detection, and viral screening.
- DropletQuant™ spectrophotometer: analyzes up to 96 samples in under five minutes, even with volumes as low as 1 μL, allowing for fast, full-spectrum assessment of sample impurities before expensive downstream processing begins. The low volume requirement and broad dynamic range enable the rapid quantitation of samples.
- cell::explorer™ Robotic Automation Platform helps researchers increase process throughput and improve data quality through highly integrated robotics. Key applications include: high-throughput screening workflows (assay plate and compound preparation), compound addition and phenotypic cell screening and immunoassay screening.
- PerkinElmer Signals™ for Screening: a platform that unites HTS and phenotypic data, enabling researchers to integrate, search and retrieve data from anywhere—inside or outside a firewall. This solution combines high-content screens with target-based assays to manage and analyze data in minutes. The platform fosters collaboration, increases efficiencies and enables faster processing in drug discovery.
PerkinElmer Poster Presentations:
- Poster 1028: “Tools for Target Validation in Cardiovascular Disease –Live Cell Imaging for Monitoring of Target Mediated Cell Migration Phenotypes and Identification of Modulating Compounds” Tuesday, February 7, 1:00 – 3:00 pm
- Poster 1092: “Distinguishing Cell Lines by Phenotypic Profiling of the Nucleus”, Tuesday, February 7, 1:00 – 3:00 pm
- “Development of twinlite, a new reagent for dual firefly and Renilla luciferase assays with improved stability”
- “Detection of receptor blocking antibody with Alpha SureFire Ultra and LANCE Ultra TR-FRET cAMP assays”
- “Developing Protein: Protein (PPI) Interaction Assays with AlphaLISA and LANCE”
- “Rapid development and analysis of 3D spheroid microtissues from multiple cancer cell lines with CellCarrier™ Spheroid ULA microplates, high content imaging, and reagents from PerkinElmer”
- “Rapid, reliable measurement of cellular proliferation and toxic compound effects on 3D spheroid cultures grown from multiple cancer cell lines with ATPlite™ 3D and ATPlite 1step 3D”
- “New Assays for Epigenetic Reader Proteins”
- “High Throughput Quantitation of Cytokine Biomarkers using LANCEUltra TR-FRET Assays”
Perkinelmer Presentations/Tutorials:
- An End-To-End 3D Cell Culture Workflow: Grow, Read, Decide, Monday, February 6, 12:30– 2:30 pm, Room 144C. In this tutorial, PerkinElmer will show an automated end-to-end workflow for 3D cell culture using state-of-the-art technology, enabling true high throughput drug discovery and toxicity testing.
- App Store and High Performance Computing for High Content Screening, Monday, February 6, 4:30 – 5:00 pm. PerkinElmer will discuss how to utilize cloud technology to solve challenges in modern laboratories.
- The Benefits of Alpha Surefire Ultra Assay Sensitivity and Modularity. Tuesday, February 7, 9:30 – 10:10 am. This tutorial will discuss Singleplex and Multiplex protein phosphorylation quantification in relevant cellular models and functional activity measurement of antibodies.
- Automating High Throughput Genomic & Phenotypic Analysis Workflows, Tuesday, February 7, 12:30 – 2:30 pm, Room 144C. PerkinElmer will provide five reasons why imaging capabilities on a multimode reader can be beneficial to laboratories.
- Making Scientific Data 100x Easier to Use, Tuesday, February 7, 4:30 – 5:00 pm. From patient to drug: developing new drug strategies for patient profiles with text analytics and literature mining.
For more information on PerkinElmer’s presence at SLAS, please visit the PerkinElmer event page.
For live coverage from the show, visit the SelectScience SLAS2017 event page.
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Infrared / IR SpectroscopyInfrared (IR) spectroscopy measures the interaction of infrared light with a sample, including transmission, reflectance & absorbance, facilitating the identification of analytes. Equipment used for quantitative analysis includes Fourier-transform infrared (FTIR) spectrometers, infrared cameras, FTIR gas analyzers, as well as attenuated total reflectance (ATR) accessories and pellet or film presses. Find the best IR spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample ManagementSample management systems include sample storage devices such as freezers and plate storers, sample environment enclosures and sample organization, retrieval and sorter systems. Useful system features include high-throughput, automation, robotic arms, automated liquid handling and associated database systems. Accessories in sample management include barcode scanners, heat sealers and tubes.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Robotic WorkstationsRobotic workstations are automated platforms enabling the user to perform high-throughput, multi-application processes, from sample preparation tasks such as PCR set-up, DNA purification and NGS library preparation, to integrated sample prep and analysis workstations. Automation makes processes consistent, fast, precise and fully walk-away. Find the best robotic workstations in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Software PlatformsSoftware platforms are useful for various stages of laboratory experiments from data collection to data storage and processing. For instance lab software is available for system control, data management, data analysis and qualification / validation.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.SLASThe Society for Laboratory Automation and Screening (SLAS) is an organization focused on laboratory automation, high-throughput screening, and biotechnology innovation. SLAS promotes scientific advancements through conferences, publications, and industry collaborations. AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.