PerkinElmer Introduces New Microplates Enabling Higher Quality Results in High Content Screening

4 Aug 2014
Charlotte Moore
Administrator / Office Personnel

Product news

PerkinElmer Inc., a global leader focused on the health and safety of people and the environment, announced the launch of its CellCarrier™ Ultra 384-well microplates, designed specifically for high content screening (HCS). The improved plate design results in higher quality image data and more robust results from HCS applications (such as phenotypic screening and three-dimensional disease model studies). This combination of capabilities provides researchers with the ability to obtain greater insights into disease and can help accelerate the discovery of new and more effective treatments.

“PerkinElmer’s depth of expertise in HCS instruments and consumables enables us to develop innovative solutions for scientists who want to measure changes in cells in an unbiased, statistically significant way -- using physiologically relevant disease models that are indicative of human physiology.” said Brian Kim, President, Life Sciences & Technology, PerkinElmer. “Innovations such as these microplates equip scientists with the tools to interrogate diseases more accurately in order to develop new and more effective treatments.”

The CellCarrier™ Ultra 384-well microplates are designed for enhanced performance in high content imaging applications where the imaging surface is critical for generating high resolution images and quality data. The plates are black and precisely engineered to have an extremely flat surface for efficient imaging. They are made using cyclic olefin, a plastic that has glass-like optical properties, to provide a clearer image.

Additional features of the microplates include better well access when using water immersion, high numerical aperture objectives with an ultra-low plate bottom, an improved lid design that reduces evaporation, corner spacers that avoid damaging the imaging surface when stacking, and a choice of different coatings to suit specific applications.

These microplates are part of PerkinElmer’s total solution for high content imaging, which includes: the Operetta® High Content Imaging System, Opera® Phenix™ High Content Screening System, Columbus™ Image Data Management and Analysis System, and HC Profiler.™

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High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell ImagingCell imaging can be achieved using a number of techniques including confocal microscopy, transmission electron microscopy, atomic force microscopy, and light sheet microscopy.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.
PerkinElmer Introduces New Microplates Enabling Higher Quality Results in High Content Screening