Oxford Gene Technology Joins CHAVI Funded Project to Provide Microarrays for HIV Vaccine Research

5 Dec 2006

Product news

Oxford Gene Technology (OGT) is pleased to announce that it has been selected to design and fabricate microarrays for the Innate Discovery Team as part of the Centre for HIV-AIDS Vaccine Immunology (CHAVI) research project to develop vaccines for HIV.

The team is led by Professor Andrew McMichael, senior scientific leader, Oxford University and Dr Persephone Borrow of the Edward Jenner Institute.

OGT will design and develop a high quality optimised oligonucleotide microarray to study genes of interest involved in the cellular immune response in early stage HIV infected patients. The microarrays will be printed using the OGT ink jet in-situ synthesis (IJISS) platform and will investigate the use of its Multi Sample Array (MSA) format enabling the parallel analysis of multiple samples. This will effectively reduce the cost per sample and speed up sample processing time.

Mr James Clough, Commercial Director at OGT said: “We are very excited to be working with Professor McMichael’s team and the wider CHAVI network. OGT’s complete microarray solution combines its bioinformatics expertise with innovative microarray technology and is well suited to the project task.”

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.
Oxford Gene Technology Joins CHAVI Funded Project to Provide Microarrays for HIV Vaccine Research