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Optimised Fluorescence for Rapid Sepsis Species Identification Assays

Alpha Laboratories Ltd
22 Jun 2015
Lois Manton-O'Byrne, PhD
Executive Editor

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QuickFISH™ is a rapid, molecular diagnostic platform, developed by AdvanDx, and now exclusively available in the UK from Alpha Laboratories. It provides 20 minute species identification of bacteria, directly from positive blood cultures. This enables clinicians to prescribe the correct antimicrobial therapy for patients with bloodstream infections much earlier, ensuring better patient outcome, reduced hospital stays and lower medical costs.

These assays are based on PNA probe technology and Fluorescence in situ Hybridisation (FISH). Alpha Laboratories now also supplies the CoolLED pE-300white microscope illumination system that gives optimal fluorescence visibility with the slide based QuickFISH™ assays. This safer alternative to a high-pressure mercury or metal-halide light source offers broad spectrum LED illumination for general use in fluorescence applications. With a comprehensive range of microscope adaptors, it can easily be fitted to most microscopes, old or new, providing a safe, convenient and economical illumination system that will last for many years without additional operating costs.

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HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Clinical MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.FluorescenceThe emission of fluorescence occurs when a photon of energy is supplied to a fluorescent chemical compound by an external source, causing it to become excited. Fluorescence can be detected and measured for different purposes using microplate readers, fluorescence microscopes, fluorescence scanners, and flow cytometers.In Situ HybridizationMolecular DiagnosticsMolecular diagnostics use an individual’s genetic code and gene expression to diagnose and monitor diseases. The technique is used increasingly in the field of infectious diseases and oncology, as well as areas such as coagulation, HLA typing and pharmacogenomics. Molecular diagnostics plays a pivotal role in personalized medicine.Blood AnalysisThe analysis of blood is vital for many areas of life sciences and forensic investigations. Blood samples can be tested for a number of different reasons such as diagnosis, glucose levels, cholesterol and drug testing.

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Optimised Fluorescence for Rapid Sepsis Species Identification Assays