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One Million Tests a Week: Accelerating Ultra High Throughput Screening

Atomo Diagnostics
7 Feb 2017
Mia Harley
Biochemist

Industry news

Analytik Jena has joined forces with Bruker Daltonics to accelerate lab processes: uHTS MALDI Sample Preparation in combination with label-free spectrometry guarantees reliable ultra high throughput screens in biopharmaceutical labs. The process will premiere at the SLAS 2017 International Conference and Exhibition in Washington D.C. from February 4-8, which focuses on innovative products and processes in lab automation and screening.

Within the framework of their cooperation, the two companies have been able to build a bridge between matrix-assisted laser desorption/ionization (MALDI) and sample preparation using automated ultra high throughput screen (uHTS). Parallel processes allow for new record speeds, with Analytik Jena’s CyBio® Well vario automated simultaneous pipettor used in the preparation of the MALDI plates. Bruker Daltonics’ rapifleX MALDI Pharma Pulse, the fastest mass spectrometer on the market, is used to analyze the plates.

The throughput of the sample prep and spotting of the MALDI target is timed to produce plates on demand for input into the rapiflex MALDI Pharma Pulse, without interruption. The entire process for each 1536-well pipetting plate requires less than ten minutes. Over one million tests are now possible each week.

Even time-intensive “sandwich” assays (matrix-assay-matrix), including the active drying of liquids on the sample carriers, can be handled by the rapifleX within the same period of time.

The CyBio® Well vario automated simultaneous pipettor has now been developed further to allow for the pipetting of 1536 wells at once, beyond mere spotting. Transfer volumes of 100 nl and more safeguard the efficient use of reagents, allowing for the highest degree of precision. An additional desalting routine, which reduces the free adducts is available to improve the analysis results.

The modular system allows for the customers to choose the degree of automation which best suites their application and workflow. Analytik Jena provides both high-quality liquid handling systems and fully automated custom solutions to meet customer needs, while also allowing for the integration of the rapifleX system.

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Plate ProcessingAutomated plate processing is used in microplate technologies for high-throughput, speed and efficiency. Plate processing systems include microplate handlers for moving plates, heat sealers, stackers and carousels for storage, retrieval and delivery, microplate washers and piercers. Useful features of plate processors include walk-away automation, compatibility and easy integration with microplate systems.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.Liquid Handling WorkstationLiquid handling workstations automate the process of sample preparation, improving accuracy and efficiency. These systems are essential for high-throughput applications in biological, chemical, and pharmaceutical research, reducing human error and increasing reproducibility. Workstations come equipped with robotic arms, pipetting tools, and other accessories to streamline lab workflows. Explore liquid handling workstations in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.High ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.

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One Million Tests a Week: Accelerating Ultra High Throughput Screening