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Novel MRI CryoProbe™ Significantly Increases Sensitivity of In-Vivo Animal Imaging

10 May 2008
Kerry Parker
CEO

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Bruker BioSpin’s pioneering CryoProbe™ technology has now been implemented for in-vivo animal MRI at 9.4 Tesla. Imaging and spectroscopy applications on mouse brain have demonstrated improvements in signal-to-noise ratio (SNR) of about 100%, or a factor of 2. Compared to the corresponding standard room temperature MRI coils, the performance of the new MRI CryoProbe leads either to an increase in imaging resolution and quality, or to a reduction in the total scan time by a factor of 4.

Bruker BioSpin’s CryoProbe technology uses cryogenic RF coils and pre-amplifiers cooled by a closed-cycle refrigeration system. As a consequence, the coil performance is improved and the noise contribution of the associated electronics is strongly reduced. Bruker BioSpin is the pioneer in the development of cryogenically cooled probes for high-resolution NMR and has installed more than 500 systems worldwide during the last seven years. This technology now for the first time is available also in the field of in-vivo animal MR imaging at 9.4Tesla, or 400 MHz proton frequency.

The first MRI CryoProbe was delivered to the University / ETH Zuerich, Switzerland in January 2006, and is routinely used for imaging applications in the neuroscience area. Professor Markus Rudin at the Animal Imaging Center, ETH Zurich, explains: “This novel MRI CryoProbe technology with its significant increase in sensitivity will greatly enhance the potential of MRI in small animals. The improvements in SNR translate, e.g., into improved quality of fMRI data or can be used to enhance spatial resolution.”

Bruker BioSpin MRI is now accepting orders for its new animal MRI CryoProbe systems for Biospec® animal MRI systems.

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NMR and EPR SpectroscopyNuclear magnetic resonance (NMR) spectroscopy is used to resolve the local chemical environment of atomic nuclei with spin, revealing information on molecular structure, dynamic processes and chemical reactions of organic molecules, from proteins to synthetics. Electron paramagnetic resonance (EPR) also known as electron spin resonance (ESR) spectroscopy is used to detect and quantify paramagnetic species in a sample, including free radicals as transition metal ions. By immersing the sample in a strong magnetic field, both NMR and EPR spectrometers probe the sample with either radio waves or microwaves respectively. A range of benchtop, solid-state and time domain NMR spectrometers & EPR spectrometers are available, as well as NMR tubes, NMR solvents, software, coils, and magnets. Find the best NMR & EPR equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.In Vivo Imaging Systems<i>In vivo</i> imaging systems, including pre-clinical imaging systems and medical imaging systems are used to non-invasively visualize and capture images of live animals and plants. Monitor the natural processes or diseases of your subjects using small-animal pre-clinical imaging systems, including single photon positron emission tomography (SPECT), positron emission tomography (PET), computed tomography (micro-CT), magnetic resonance imaging (MRI), X-ray radiography, ultrasound, fluorescence and bioluminescence imagers. Multimodal systems and software solutions are also available for correlative analysis of organ, tissue, cell, or molecular-level processes. Find the best in vivo imaging products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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Novel MRI CryoProbe™ Significantly Increases Sensitivity of In-Vivo Animal Imaging