SelectScience
Join Free
Accelerating Science
NewsLife Sciences

Novel Lateral Flow Point-of-Care Assays Expand Boundaries of Clinical Diagnostics

24 Jul 2012
Sonia Nicholas
Managing Editor and Clinical Lead

Product news

Genisphere showcased its revolutionary point-of-care technology at AACC last week. The company has adapted its pioneering 3DNA Dendrimer Signal Amplification technology for Lateral Flow (LF) Point-of-Care (POC) assays, providing improved sensitivity and enabling a broad new array of POC tests.

LF assays represent a unique and growing class of POC tests designed to rapidly diagnose patients within clinically actionable timeframes. Genisphere’s 3DNA® signal amplifiers will enable the commercialization of new LF assays that otherwise could not be launched due to unacceptably low sensitivity and will help test-makers differentiate themselves in the competitive POC testing market, which is flooded with products that are limited by both sensitivity and quantitative accuracy.

These developments build on previous signal amplification capabilities that have been demonstrated in other systems such as ELISA, protein and DNA arrays, as well as Luminex® assays.

“Genisphere’s game-changing 3DNA® technology provides an improvement of sensitivity in lateral flow assays that no other system has been able to achieve,” said Jim Kadushin, vice president and chief operating officer, Genisphere. “Genisphere has accomplished its goal of providing a robust and easy-to-use reagent that manufacturers can drop into their existing bioassay platform with very little adaptation and no end user modifications required. We look forward to exploring a range of strategic partnering opportunities.”

Genisphere’s proprietary 3DNA® Dendrimer technology has delivered up to 64-fold improvements in sensitivity over standard, non-dendrimer assays. With this heightened power of detection, the technology can reduce false negatives and significantly increase the accuracy of otherwise-subjective outcome readings.

The technology will expand the POC market to more sensitive rapid-testing for a wide list of conditions such as infectious diseases, bacterial sepsis, coronary biomarkers, food microbiological testing, and environmental and water testing that are outside the analytical reach of current systems.

Tags

Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.AACCThe American Association for Clinical Chemistry (AACC) Annual Meeting and Clinical Lab Expo is the largest meeting for clinical laboratory professionals in the world. This year's meeting is being held in Atlanta, USA, July 26th-30th, 2015.Point of Care SolutionsPoint of care solutions provide medical diagnostics and treatments at or near the site of patient care. These technologies offer rapid results, helping healthcare providers make quick decisions. From glucose monitors to molecular diagnostics, point of care solutions are transforming healthcare delivery by reducing wait times and improving patient outcomes. Explore the best point of care products in our peer-reviewed product directory, compare options, check reviews, and get pricing directly from manufacturers.

Related articles

Novel Lateral Flow Point-of-Care Assays Expand Boundaries of Clinical Diagnostics