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News From the Forefront of Cancer Diagnostics

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SelectScience publishes breaking news from the cancer diagnostics industry

15 Feb 2016
Sonia Nicholas
Managing Editor and Clinical Lead

Editorial article

The field of cancer diagnostics moves rapidly, as scientists around the world pour resources into finding new solutions, diagnostics and treatments


In this article, we highlight some of the very latest cancer diagnostic news, including new partnerships using next generation sequencing technology, brand new diagnostic cancer tests, and an interesting look at the ‘elephants in the room’ with regards to whole slide imaging.

1. Swift Biosciences and SeraCare Partner on Circulating Tumor DNA Standards for NGS-Based Oncology Assays

Swift Biosciences, developer of innovative technologies for genomics research, and SeraCare Life Sciences, a manufacturer and leading partner to global in vitro diagnostics manufacturers, have announced a partnership to accelerate development of a novel circulating tumor DNA reference material.

2. Elephants in the Room – Whole Slide Imaging

Mark Clymer, from Datacolor Scientific, discusses the ‘elephants in the room’ for whole slide imaging (WSI) manufacturers. This article is written in the wake of the Digital Pathology Association’s announcement that the ‘de novo’ application process may be acceptable by the FDA for clearance of WSI devices for diagnostic uses.

3. Agena Bioscience Partners with DaRui Biotech to Bring MassARRAY Technology to the Diagnostics Market in China

Agena Bioscience recently announced its partnership with DaRui Biotechnology to co-develop a menu of in vitro diagnostic tests for oncology and inherited diseases on its MassARRAY® System for targeted genetic analysis.

4. Fecal Immunochemical Testing (FIT) is Cost Effective Compared to Colonoscopy

The new NICE guidelines [NG12] for “Suspected cancer: recognition and referral” have recommended Fecal Occult Blood Testing (FOBT) as a cost effective method in primary care, for detecting colorectal cancers in people aged 40 or older with a change in bowel habit.

5. MDxHealth Analytical Validation Study on AssureMDx for Bladder Cancer Published in The Journal of Urology

MDxHealth SA has announced that data demonstrating the clinical potential of its urine-based epigenetic bladder cancer test AssureMDx, to aid urologists in the management of patients presenting with hematuria (blood in the urine), has been published in The Journal of Urology.

Visit the Cancer Diagnosis Special Feature for the latest news about cutting-edge technologies.

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HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Cancer DiagnosticsThere are a wide variety of diagnostic tests for cancer available, and this range continues to expand as our knowledge of cancer improves. Current diagnostic methods include biopsy, imaging and blood tests for known biomarkers. New methods in research development include liquid biopsies and cancer breathalyzers.Clinical NGSNext Generation Sequencing (NGS) refers to the use of massive parallel sequencing of multiple small fragments of DNA. This high-throughput genomic analysis yields enormous amounts of sequence data, which if appropriately analyzed could have huge potential for clinical laboratories. For this to happen there are technique and bioinformatic hurdles to be overcome.Liquid BiopsiesLiquid biopsies are non-invasive tests used to detect cancer and other diseases by analyzing blood or other bodily fluids. This technique is gaining popularity for early detection, monitoring treatment response, and detecting minimal residual disease. Explore liquid biopsy solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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