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New Waters Software Extends the Proteomics Capabilities of the Progenesis QI

20 Mar 2017
Lois Manton-O'Byrne, PhD
Executive Editor

Product news

Waters Corporation announced that it will now offer Proteolabels, a new software that has been designed as an extension for Progenesis® QI for proteomics users and researchers. Proteolabels supports studies involving stable isotope labels, such as “SILAC” and dimethyl labeling in duplex or triplex. Waters® is offering Proteolabels through an exclusive agreement with Omic Analytics, an innovative start-up based in Liverpool, UK.

“At Omic Analytics, we are very excited to be collaborating with Waters on this new venture. We look forward to seeing Proteolabels in action with scientists all over the world”

“Waters takes great pride in working with innovative research groups like Omic Analytics to develop effective solutions to solve customer needs,” said Dr. Steve Smith, Vice President Informatics at Waters. “Proteolabels extends the use of Progenesis QI for proteomics, a need for many of our customers working in health sciences, along with a growing number in food and environmental research.”

Proteolabels was engineered with a focus on performance and usability, empowering scientists to explore their data and achieve high-quality results. Features include:

  • Co-detection: The workflow builds upon the Progenesis QI for proteomics co-detection feature, in which features are aligned across LC-MS runs to improve sensitivity and reproducibility.
  • Auto-detect: Proteolabels makes a first pass through the data to suggest optimal parameters, simplifying the analysis.
  • Peptide scoring: Proteolabels contains novel metrics for scoring the quality of pairs/triples detected, enabling users to measure the reliability of quantitation down to the level of each peptide.
  • Intelligent protein inference: Intelligent weighted averaging of different peptide-level signals is performed, to give more accurate protein-level quantitation results.
  • QC metrics: Proteolabels contains a large number of QC metrics and data plotting options, enabling users to interact and explore their data, and, where needed, make decisions as to how arrive at the best protein set.

“At Omic Analytics, we are very excited to be collaborating with Waters on this new venture. We look forward to seeing Proteolabels in action with scientists all over the world,” said Prof Andy Jones, Director of Omic Analytics Ltd, UK.

Tags

ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.Data AnalysisThe analysis of data is the process of transforming, modeling and evaluating data to discover useful information from experimental results.

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New Waters Software Extends the Proteomics Capabilities of the Progenesis QI