New ultra-fast Nexera QX Multiplex LC-MS/MS system multiplies sample throughput to maximize productivity

21 Dec 2020
Meg Hicks
Student / Graduate

Product news

Shimadzu Scientific Instruments introduces the Nexera QX Multiplex LC-MS/MS system that uses multiple, alternating sample introduction streams for continuous operation of the mass spectrometer to significantly increase laboratory throughput and profitability.

Nexera QX Multiple Stream technology eliminates waiting for column equilibration and system flushing. Nexera SIL-40 UHPLC autosamplers, stream-dedicated injection valves and washing pumps deliver ultra-fast performance with ultra-low carryover.

The Nexera QX System adds multiple injection valves to the Nexera SIL-40 series autosampler, the industry standard for fast and clean injections. It also intelligently controls dedicated Nexera UHPLC pumps to automate flow line rinsing of each analytical stream to mitigate carryover from extreme samples.

Newly developed QX Solution software provides an automated single point of control for multiple UHPLC streams and the mass spectrometer for a multiplexed workflow. QX Solution simplifies valve switching, gradient control and injection timing and can execute automatic flushing from dedicated pumps to reduce autosampler and column carryover to a minimum. Specifically designed for the high-throughput laboratory, the system features the easy import of spreadsheet sample batches.

The Nexera QX system delivers industry-leading robustness, sensitivity and detection speeds with Shimadzu’s most powerful tandem mass spectrometer, the LCMS-8060NX triple quadrupole mass spectrometer.

The new IonFocus electrospray unit and newly designed ion guides deliver robust operation through reduced matrix effects and less contamination inside the instrument. This results in maximized uptime, superior data quality, and a more efficient analytical workflow.

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Nexera LC-40 series

Shimadzu has long been advancing the analytical performance of HPLC systems. At the same time, we recognize that overall efficiency depends not only on the performance of one instrument, but on the management of all devices within a lab. This realization leads us to now, a time in which AI capabilities have been incorporated to allow devices to detect and resolve issues automatically. In addition, lab management has ben integrated using the Internet of Things (IoT) and device networking, making it simple to review the status of instruments and optimize resource allocation. Building upon 40 years of experience in LC technology, the Nexera series is a family of HPLC systems that marries these AI and IoT enhancements to set new industry.

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Nexera HPLC System

Shimadzu's Nexera is a genuine all-around HPLC that enables various types of analysis including conventional LC, ultra fast LC and ultra high-pressure LC up to 130 MPa without compromising performance and data quality. The LC-30A Nexera delivers high-speed and high-resolution analysis without sacrificing basic performance parameters such as excellent precision, near-zero carryover, good linearity, stability and ruggedness. Offering these attributes enables Nexera to provide superior performance in various fields, covering high-resolution and high-speed separation, as well as high-sensitivity detection. Features of the Shimadzu LC-30A Nexera include: • New zero carryover• Absorbance detectors with excellent stability and sensitivity• Precise sample injection regardless of volume• Finest Reproducibility under Ultra-High Speed• Reduced otal analysis time• Large sample capacity for high throughput sample analysis

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Ion ChromatographyIon chromatography, also known as ion exchange chromatography, is a high-performance liquid chromatographic technique used for the separation and identification of ions or polar molecules in a sample, including proteins, nucleotides and amino acids. Equipment includes ion exchange columns, ion exclusion columns, ion chromatography systems, pumps, and detectors. Find the best ion chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.LC-MSLiquid Chromatography-Mass Spectrometry (LCMS) is a powerful analytical technique that combines the separation power of liquid chromatography with the detection capabilities of mass spectrometry. It is widely used for qualitative and quantitative analysis of complex mixtures in pharmaceuticals, proteomics, and environmental studies. Browse our peer-reviewed product directory to find the best LCMS systems, compare products, check reviews, and get pricing directly from manufacturers.